{"product_id":"metallo-drugs-development-and-action-of-anticancer-agents-9783110469844","title":"Metallo-Drugs: Development and Action of Anticancer Agents","description":"\u003cp\u003eVolume 18, entitled \u003cem\u003eMetallo-Drugs: Development and Action of Anticancer Agents\u003c\/em\u003e of the series \u003cem\u003eMetal Ions in Life Sciences\u003c\/em\u003e centers on biological, medicinal inorganic chemistry. The serendipitous discovery of the antitumor activity of \u003cem\u003ecis\u003c\/em\u003e-diamminodichloroplatinum(II) (cisplatin) by Barnett Rosenberg in the 1960s is a landmark in metallodrug-based chemotherapy. The success of cisplatin in the clinic, followed by oxaliplatin and carboplatin, along with their drawbacks relating mainly to resistance development and severe toxicity, initiated research on polynuclear platinum complexes and on Pt(IV) complexes as prodrugs. Furthermore, the indicated shortcomings led to the exploration of other transition and main group metal ions, among them Ru(II\/III), Au(I\/III), Ti(IV), V(IV\/V), and Ga(III) including also the essential metal ions Fe(II\/III), Cu(I\/II), and Zn(II). Ionic as well as covalent and non-covalent interactions between structurally very different complexes and biomolecules like nucleic acids, proteins, and carbohydrates are studied and discussed with regard to their possible anticancer actions. Hence, \u003cem\u003eMILS-18\u003c\/em\u003e summarizes the research at the forefront of medicinal inorganic chemistry, including studies on the next-generation, tailor-made anticancer drugs. All this and more is treated in an authoritative and timely manner in the \u003cstrong\u003e17\u003c\/strong\u003e stimulating chapters of this book, written by \u003cstrong\u003e39\u003c\/strong\u003e internationally recognized experts from \u003cstrong\u003e10\u003c\/strong\u003e nations (from the US via Europe to China and Australia). The impact of this vibrant research area is manifested by more than \u003cstrong\u003e2700\u003c\/strong\u003e references, nearly \u003cstrong\u003e150\u003c\/strong\u003e illustrations (more than half in color) and several comprehensive tables. \u003cem\u003eMetallo-Drugs: Development and Action of Anticancer Agents\u003c\/em\u003e is an essential resource for scientists working in the wide range from enzymology, material sciences, analytical, organic, and inorganic biochemistry all the way through to medicine including the clinic ... not forgetting that it also provides excellent information for teaching. \u003c\/p\u003e","brand":"Astrid Sigel","offers":[{"title":"Default Title","offer_id":48262598230267,"sku":"9783110469844","price":370.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0779\/3917\/9771\/files\/CoreSourceHub_1a944d1a-d475-4bb6-ab6c-038370b2edc6.jpg?v=1778534689","url":"https:\/\/indiepubs.com\/products\/metallo-drugs-development-and-action-of-anticancer-agents-9783110469844","provider":"IndiePubs","version":"1.0","type":"link"}