{"product_id":"the-integration-of-adverse-outcome-pathways-and-aggregate-exposure-pathways-for-food-safety-testing-pesticides-as-a-case-study-9781835455968","title":"The integration of adverse outcome pathways and aggregate exposure pathways for food safety testing: pesticides as a case study","description":"\u003cp\u003eChemical risk assessment is moving towards non-animal approaches that rely on the mechanistic understanding of toxicity. In this respect, the adverse outcome pathway (AOP) framework is a promising tool to capture chemical-agnostic mechanistic understanding of toxicological processes. AOPs link a molecular initiating event to a specific adverse outcome via a series of key events and key event relationships. Sharing common key features to the AOP framework, the aggregate exposure pathway (AEP) framework is a complementing tool to systematically collect chemical-specific exposure information from the source to the site of action via key exposure states and key transitional relationships. Integrating exposure and toxicological knowledge into combined AEP-AOP constructs can facilitate prediction of chemical-induced toxicity and enable risk-based decision making. The current chapter focuses on the structure, development, assessment, and applications of the AOP and AEP frameworks, illustrated by a case-study on the hepatotoxicity of the metabolites and environmental residues of pesticides.\u003c\/p\u003e","brand":"Professor Mathieu Vinken","offers":[{"title":"Default Title","offer_id":48281145409787,"sku":"9781835455968","price":32.5,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0779\/3917\/9771\/files\/CoreSourceHub_20f7547c-f03e-4e73-8a5e-07e40c0c5d24.jpg?v=1776143541","url":"https:\/\/indiepubs.com\/products\/the-integration-of-adverse-outcome-pathways-and-aggregate-exposure-pathways-for-food-safety-testing-pesticides-as-a-case-study-9781835455968","provider":"IndiePubs","version":"1.0","type":"link"}