Effective cultivation of commercial citrus in the event of a Huanglongbing (HLB) outbreak depend on the development and implementation of Integrated Pest Management (IPM) for Asian citrus psyllid (ACP), Diaphorina citri Kuwayama and HLB grounded in understanding of conditions fostering biological control, reducing tree inoculation, and placed within the context optimizing resistance management practices. This chapter offers a historical perspective on IPM in Florida citrus, and outlines the response to Huanglongbing as well as current and future approaches to this challenge. The chapter looks ahead to future research trends.