This chapter reviews the latest scientific studies on the health benefits of apples, including fresh, canned, frozen, dried and/or juice (clear and cloudy) and their phytochemicals. Due to their popularity, accessibility and high nutritional content, apples have been the subject of many scientific studies targeting chronic disease prevention. Their consumption has been correlated with positive outcomes for a variety of diseases, including cancer, diabetes, osteoporosis, cardiovascular disease, cognitive and lung disorders.