The Renaissance witnessed an upsurge in explanations of natural events in terms of invisibly small particles – atoms, corpuscles, minima, monads and particles. The reasons for this development are as varied as are the entities that were proposed. This volume covers the period from the earliest commentaries on Lucretius’ De rerum natura to the sources of Newton’s alchemical texts. Contributors examine key developments in Renaissance physiology, meteorology, metaphysics, theology, chymistry and historiography, all of which came to assign a greater explanatory weight to minute entities. These contributions show that there was no simple ‘revival of atomism’, but that the Renaissance confronts us with a diverse and conceptually messy process. Contributors are: Stephen Clucas, Christoph Lüthy, Craig Martin, Elisabeth Moreau, William R. Newman, Elena Nicoli, Sandra Plastina, Kuni Sakamoto, Jole Shackelford, and Leen Spruit.