The book offers a fresh perspective on a seemingly well-known and vexed issue: the relationship between the autonomy of EU law and international dispute settlement bodies. It provides a deep-dive into the how and why autonomy operates differently across various types of mechanisms, and provides a valuable synthesis that, in addition to being useful to specialists, is also accessible to people starting their involvement with the field. A thorough analysis of the up-to date jurisprudence of not only EU-, but also international courts makes it interesting also for legal practitioners and those interested more broadly in the broader issues of interaction between international dispute settlement frameworks.