Climate-resilient Agriculture and Food Security: Innovations, Strategies, and Sustainability presents an inclusive, interdisciplinary exploration of how agricultural systems can adapt, transform, and thrive amid accelerating climate change. The book unites cutting-edge research with policy insights and field-based evidence to examine climate variability, ecosystem integrity, crop productivity, livestock systems, food safety, and rural livelihoods across diverse global contexts. The book spans foundational principles of climate-resilient agriculture, biodiversity conservation, and natural resource management, while advancing discussions on biotechnology, multi-omics, metabolomics, and epigenetic engineering for developing stress-tolerant crops. It highlights the critical role of microbial alliances, agroforestry, legume-cereal rotation systems, and indigenous knowledge systems in enhancing agroecosystem resilience. Dedicated chapters address livestock sustainability, methane mitigation through phytonutrients, microbial biopesticides, and fungal climate adaptability.The volume establishes a connection between scientific knowledge and community understanding through its analysis of gender-responsive technology adoption patterns, AI-based weather forecasting, farmer adaptation behaviour, and region-specific resilience strategies across Africa and beyond. The study expands the existing discourse on food safety and public health within the One Health framework, underscoring emerging climate-sensitive risks.The book presents practical solutions for researchers, policymakers and development practitioners and advanced students committed to building sustainable food systems, equitable and climate-ready food systems through the integration of ecological, technological, socio-economic and policy perspectives. The study serves as a reference resource for scholars while providing operational guidance to protect global food security in an era of unprecedented environmental change.