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The dynamic field of flavin and flavoprotein biochemistry has seen rapid advancement in recent years. This comprehensive two volume set provides an overview of all aspects of contemporary research in this important class of enzymes. Topics treated include flavoproteins involved in energy generation, signal transduction and electron transfer (including respiration); oxygen activation by flavoproteins; the biology and biochemistry of complex flavoproteins; flavin and flavoprotein photochemistry/photophysics as well as biotechnological applications of flavoproteins. Recent developments in this field include new structures (including those of large membrane-integral electron transfer complexes containing FMN or FAD), elucidation of the role of flavoproteins in cell signalling pathways (including both phototaxis and the circadian cycle) and important new insights into the reaction mechanisms of flavin-containing enzymes. This volume focusing on complex flavoproteins and physical methods is an essential reference for all researchers in biochemistry, chemistry, photochemistry and photophysics working on flavoenzymes.
Russ Hille, University of California, Riverside, CA, USA; Susan Miller, University of California, San Francisco, CA, USA; Bruce Palfey, University of Michigan, Ann Arbor, MI, USA.
I. Flavoproteins in Energy Generation
A. NADH dehydrogenase
B. Acyl-CoA dehydrogenases
C. Electron-transferring flavoprotein
D. Lipoamide dehydrogenase, glutathione reductase and other transhydrogenases
E. Succinate Dehydrogenase and fumarate reductase
F. Ferredoxin:NADP+ oxidoreductase
II. Complex Flavoproteins
A. Nitrate reductases
B. Xanthine oxidoreductase and related enzymes
C. Phthalate dioxygenase reductase
D. Cytochrome P-450 reductase
E. Flavocytochrome b2
III. Oxygen Activation by Flavoproteins
A. D-amino acid oxidase and related enzymes
B. Cholesterol oxidase
C. Flavin monooxygenases
D. Nitroreductases
IV. Flavin Amine Oxidases
A. Monoamine oxidases
B. Trimethylamine and dimethylamine dehydrogenases
C. Histone-lysine demethylases
V. Flavoproteins and Light
A. DNA photolyase
B. Plant blue-light receptor
C. Flavoproteins of the Circadian cycle
D. Luciferase and related systems
VI. The Chemistry of Flavins
A. Oxidation-reduction and electron transfer chemistry
B. Covalent modification of flavoproteins
C. Unconventional flavins in chemsitry and biology
D. Photophysics of flavins