Destination competitiveness and sustainability are important issues for many stakeholders within the tourism industry. In recent years, destinations have faced some challenges with respect to maintaining sustainability; they must be cleaner, greener and safer in order to safeguard the life quality of holidaymakers and local residents. Providing an invaluable review of the latests research on the topic, global case studies provide a perspective of the worldwide challenges and solutions arising in the management of tourism destinations. The analysis presents an interdisciplinary approach, including contributions of economists, geographers, managers and marketing professionals.