In the shifting landscapes of global drug governance, power asymmetries shape drug economies as well as policy discourses. Through counternarratives and regional case studies of the Americas, this edited volume investigates how prohibition, securitization, and regulation intertwine in the production of violence and inequality. Bridging fresh interdisciplinary studies and critical policy analysis, the contributors provide conceptual and empirical insights toward more reflexive, context-sensitive, and emancipatory approaches to drug policies.