Ruthenberg highlights the unique aspects of chemistry, specifically its metachemical fundamentals, which have been largely overlooked in current philosophies of science. Conventional metaphysics, derived from or focused on theoretical physics, is inadequate when applied to chemistry. The author examines and integrates historical and philosophical perspectives on important aspects of chemistry, including affinity, compositionism, emergence, synthesis/analysis, atomism/non-atomism, chemical species, chemical bond, chemical concepts, plurality, temporality/potentiality, reactivity, and underdetermination. To accomplish this, he draws on the works of notable chemists such as František Wald, Wilhelm Ostwald, Friedrich Paneth, and Hans Primas, who have contributed to the philosophical understanding of chemistry. The central conclusion of this study aligns with Immanuel Kant's viewpoint: Chemistry is a systematic art.