Fostering a dialog between Critical Disability Studies, American Studies, InterAmerican Studies, and Global Health Studies, the edited compilation conceptualizes disability and (mental) illnesses as a cultural narrative enabling a deeper social critique. By looking at contemporary cultural productions primarily from the USA, Canada, and the Caribbean, the books’ objective is to explore how literary texts and other cultural productions from the Americas conceptualize, construct, and represent disability as a narrative and to investigate the deep structures underlying the literary and cultural discourses on and representations of disability including parameters such as disease, racism, and sexism among others. Disability is read as a shifting phenomenon rooted in the cultures and histories of the Americas.