Frontmatter -- Editors -- List of first-mentioned contributors -- Preface -- Contents -- Research methods and the discovery of insulin -- The discovery of the oral treatment of diabetes mellitus with sulphonylureas -- Epidemiological research methodologies for the study of the aetiology of IDDM -- Epidemiological research methodologies for NIDDM -- Methodological concerns in diagnosing the prediabetic state -- Genetic patterns of IDDM related to environmental factors -- Immune mechanisms of beta cell destruction in the prediabetic phase of IDDM patients: research methodologies identifying susceptible individuals -- Interventions attempting at preventing or ameliorating the development of type 1 diabetes -- Assays for measuring proinsulin, insulin, and related peptides -- Assessment of insulin production and secretion dynamics in health and disease, including diabetes -- Methodologies in characterization and classification of prediabetic states to non-insulin-dependent diabetes mellitus (NIDDM) -- Research methodologies in hypoglycaemia: counterregulation phenomena and nerve/brain dysfunction -- Methods in evaluating lipoprotein and triglyceride metabolism in diabetes -- Research methodologies in the evaluation of intestinal glucose absorption and the concept of glycaemic index -- Evaluation of cardiac autonomic neuropathy by heart rate variability -- Methodologies in sodium-lithium countertransport as related to other cation transport systems in diabetes -- Methods in the assessment of transcapillary escape rate of plasma proteins -- Measurement of advanced glycosylation endproducts -- Research methodologies in the evaluation of home glucose monitoring -- Measurements of glycated haemoglobin and other circulating glycated proteins -- Research methodologies in evaluating patient education in diabetes — to reflect on the goals of patient education -- Research methodologies in diabetic retinopathy -- Methodologies to assess renal function in diabetes mellitus -- Conducting clinical trials in diabetic eye disease -- Economic analysis in diabetes -- Research methodologies in connective tissue changes and diabetic skin disease -- Measurement of extracellular fixed anionically charged molecules -- Methods in measuring glucose transporters and insulin receptors in target cells from humans -- World Medical Association Declaration of Helsinki -- Subject index