In this volume, a group of scholars from moral philosophy, epistemology, metaphysics, and the history of philosophy explore the ideas of nature and naturalism as they occur in the celebrated responses to scepticism offered by David Hume, Ludwig Wittgenstein, and P. F. Strawson. Philosophers have long been puzzled by the fact that each of these figures approaches scepticism by emphasising certain general facts about human nature. There has also been a debate over how these philosophers’ discussions of scepticism were shaped by their wider views on naturalism as a philosophical orientation that prioritises the natural sciences. This is the first volume to offer a comprehensive and comparative exploration of the guiding themes of scepticism and naturalism in the work of these three great figures.