A sustainable cassava seed system will ensure that high-quality seeds of farmer-demanded varieties and crops are produced and fully available on time and affordable to farmers and other stakeholders. This chapter describes the production and management of high-quality cassava seed under both informal and formal seed systems, and under both traditional and different types of rapid propagation methods. The chapter includes a detailed case study on mini-stake-based rapid multiplication in India and looks ahead to future developments in this area of research.