Sherlock Holmes and Dr. Watson continue their 1892 Canadian travels, by stagecoach, sleigh, horse, train, naval ship, inland canoe and fifty-foot war canoe, making their way across the prairies, through the Rockies, to Vancouver Island and north to Cariboo country. In Calgary, they assist Superintendent Sam Steele of the N.W.M.P. in his inquiries, to track down "cattle thieves, whiskey smugglers, rogues and confidence men." On an exhilarating ride through Kicking Horse Pass, they share the cow catcher with Sarah Bernhardt, whose Vancouver performance of La Dame aux camélias is, writes Watson, "undoubtedly the most moving theatrical experience I have ever had."

Sherlock Holmes: Travels in the Canadian West is the final book in a trilogy of Holmes in Canada by Ronald C. Weyman. Quebec City and the St. Lawrence River are the setting for Sherlock Holmes and the Mark of the Beast; in Sherlock Holmes and the Ultimate Disguise the Londoners visit Toronto, Niagara Falls and (though not by choice) the Kingston Penitentiary.