This chapter examines the challenges and opportunities for targeting smallholder farmers to adopt improved cassava technologies for yield and profitability. Smallholder farmers are not a homogenous group and, therefore, a static technology promotion system cannot address the needs of a dynamic client group. Using evidence from existing research, the chapter explores how key issues are being addressed. It reviews three case studies, including the Fufu Project and C:AVA, which show research being used in practice to improve cassava productivity among smallholders. Finally, it provides an insight into future trends in research on targeting smallholder farmers to adopt improved cassava technologies.