Weed control in cassava fields appears to have received highly variable levels of attention on the different continents where cassava is grown, despite clear messages from farming communities on its importance. Moreover, although grasses and broadleaved weeds are perceived as a major problem in cassava cultivation, the crop is one of the few without concrete chemical and mechanical weed control options. This chapter will discuss the effects of weeds on cassava root yields, farmers’ perceptions of the importance of weed control and the control methods used in different cropping systems. The focus is primarily on Africa, due to the fact that the continent accounts for the largest portion of global cassava production, weed control is not as well developed there and weeds pose a larger threat to livelihoods in Africa than in South America or Asia.