Medical

There is a persistent gap in life expectancy between Black people and their white counterparts in the United States. It is a direct result of structural racism within American society and has nothing to do with genetic differences. In past eras, scientific racism sought to shift the blame to the supposed physical inferiority of people of African descent. Even today, medicine labors under false beliefs derived from nineteenth-century racial thinking, harming patients who are not of European descent.

Why Black People Die Sooner is a powerful and rigorous examination of the ways racism shapes health and disease. Joseph L. Graves Jr. demonstrates that the medical profession still fails to grasp basic facts about race, tracing how deep-rooted falsehoods have perpetuated the disparity between Black and white lifespans. He equips readers with the tools to dispel the fallacies and errors of racialized medicine, including an understanding of evolutionary biology and human biological variation. Graves also debunks common misconceptions about race and health on topics such as high blood pressure, sickle cell disease, the microbiome, infectious diseases, and cancer. Why Black People Die Sooner closes by offering a sweeping vision for dismantling medical racism, from professional training to clinical practice through biomedical research. Timely and bracing, this book reveals why medicine keeps misunderstanding race—and how we can make it change.

Science doesn’t speak for itself. Neck-deep in work that can be messy and confounding and naïve in the ways of public communication, scientists are often unable to package their insights into the neat narratives that the public requires. Enter celebrities, advocates, lobbyists, and the funders behind them, who take advantage of scientists’ reluctance to provide easy answers, flooding the media with misleading or incorrect claims about health risks. Amid this onslaught of spurious information, Americans are more confused than ever about what’s good for them and what isn’t.

In Bad Advice, Paul A. Offit shares hard-earned wisdom on the dos and don’ts of battling misinformation. For the past twenty years, Offit has been on the front lines in the fight for sound science and public heath. Stepping into the media spotlight as few scientists have done—such as being one of the first to speak out against conspiracy theories linking vaccines to autism—he found himself in the crosshairs of powerful groups intent on promoting pseudoscience. Bad Advice discusses science and its adversaries: not just the manias stoked by slick charlatans and their miracle cures but also corrosive, dangerous ideologies such as Holocaust and climate-change denial. Written with wit and passion, Offit’s often humorous guide to taking on quack experts and self-appointed activists is a must-read for any American disturbed by the uptick in politicized attacks on science.

The past thirty years have witnessed a revolution in the science of addiction, yet we still rely on outdated methods of treatment. Expensive new programs for managing addiction are also flourishing, but since they are not based in science, they offer little benefit to people who cannot afford to lose money or faith in their recovery.

Clarifying the cutting-edge science of addiction for both practitioners and general readers, The Thirteenth Step pairs stories of real patients with explanations of key concepts relating to their illness. A police chief who disappears on the job illustrates the process through which a drug can trigger the brain circuits mediating relapse. One person's effort to find a burrito shack in a foreign city illuminates the reward prediction error signaled by the brain chemical dopamine. With these examples and more, this volume paints a vivid, readable portrait of drug seeking, escalation, and other aspects of addiction and suggests science-based treatments that promise to improve troubling relapse rates. Merging science and human experience, The Thirteenth Step offers compassionate, valuable answers to anyone who hopes for a better handle on a confounding disease.

Science doesn’t speak for itself. Neck-deep in work that can be messy and confounding and naïve in the ways of public communication, scientists are often unable to package their insights into the neat narratives that the public requires. Enter celebrities, advocates, lobbyists, and the funders behind them, who take advantage of scientists’ reluctance to provide easy answers, flooding the media with misleading or incorrect claims about health risks. Amid this onslaught of spurious information, Americans are more confused than ever about what’s good for them and what isn’t.

In Bad Advice, Paul A. Offit shares hard-earned wisdom on the dos and don’ts of battling misinformation. For the past twenty years, Offit has been on the front lines in the fight for sound science and public heath. Stepping into the media spotlight as few scientists have done—such as being one of the first to speak out against conspiracy theories linking vaccines to autism—he found himself in the crosshairs of powerful groups intent on promoting pseudoscience. Bad Advice discusses science and its adversaries: not just the manias stoked by slick charlatans and their miracle cures but also corrosive, dangerous ideologies such as Holocaust and climate-change denial. Written with wit and passion, Offit’s often humorous guide to taking on quack experts and self-appointed activists is a must-read for any American disturbed by the uptick in politicized attacks on science.

The past thirty years have witnessed a revolution in the science of addiction, yet we still rely on outdated methods of treatment. Expensive new programs for managing addiction are also flourishing, but since they are not based in science, they offer little benefit to people who cannot afford to lose money or faith in their recovery.

Clarifying the cutting-edge science of addiction for both practitioners and general readers, The Thirteenth Step pairs stories of real patients with explanations of key concepts relating to their illness. A police chief who disappears on the job illustrates the process through which a drug can trigger the brain circuits mediating relapse. One person's effort to find a burrito shack in a foreign city illuminates the reward prediction error signaled by the brain chemical dopamine. With these examples and more, this volume paints a vivid, readable portrait of drug seeking, escalation, and other aspects of addiction and suggests science-based treatments that promise to improve troubling relapse rates. Merging science and human experience, The Thirteenth Step offers compassionate, valuable answers to anyone who hopes for a better handle on a confounding disease.

A leading authority explains the ideas and practice of Chinese medicine from its beginnings in antiquity to today. Paul U. Unschuld describes medicine's close connection with culture and politics throughout Chinese history. He brings together texts, techniques, and worldviews to understand changing Chinese attitudes toward healing and the significance of traditional Chinese medicine in both China and the Western world.

Unschuld reveals the emergence of a Chinese medical tradition built around a new understanding of the human being, considering beliefs in the influence of cosmology, numerology, and the supernatural on the health of the living. He describes the variety of therapeutic approaches in Chinese culture, the history of pharmacology and techniques such as acupuncture, and the global exchange of medical knowledge. Insights are offered into the twentieth-century decline of traditional medicine, as military defeats caused reformers and revolutionaries to import medical knowledge as part of the construction of a new China. Unschuld also recounts the reception of traditional Chinese medicine in the West since the 1970s, where it is often considered an alternative to Western medicine at the same time as China seeks to incorporate elements of its medical traditions into a scientific framework. This concise and compelling introduction to medical thought and history suggests that Chinese medicine is also a guide to Chinese civilization.

A leading authority explains the ideas and practice of Chinese medicine from its beginnings in antiquity to today. Paul U. Unschuld describes medicine's close connection with culture and politics throughout Chinese history. He brings together texts, techniques, and worldviews to understand changing Chinese attitudes toward healing and the significance of traditional Chinese medicine in both China and the Western world.

Unschuld reveals the emergence of a Chinese medical tradition built around a new understanding of the human being, considering beliefs in the influence of cosmology, numerology, and the supernatural on the health of the living. He describes the variety of therapeutic approaches in Chinese culture, the history of pharmacology and techniques such as acupuncture, and the global exchange of medical knowledge. Insights are offered into the twentieth-century decline of traditional medicine, as military defeats caused reformers and revolutionaries to import medical knowledge as part of the construction of a new China. Unschuld also recounts the reception of traditional Chinese medicine in the West since the 1970s, where it is often considered an alternative to Western medicine at the same time as China seeks to incorporate elements of its medical traditions into a scientific framework. This concise and compelling introduction to medical thought and history suggests that Chinese medicine is also a guide to Chinese civilization.

Lyme disease is the most common tick-borne illness in the United States, with more than 300,000 cases diagnosed each year. However, doctors are deeply divided on how to diagnose and treat it, giving rise to the controversy known as the “Lyme Wars.” Firmly entrenched camps have emerged, causing physicians, patient communities, and insurance providers to be pitted against one another in a struggle to define Lyme disease and its clinical challenges. Health care providers may not be aware of its diverse manifestations or the limitations of diagnostic tests. Meanwhile, patients have felt dismissed by their doctors and confused by the conflicting opinions and dubious self-help information found online.

In this authoritative book, the Columbia University Medical Center physicians Brian A. Fallon and Jennifer Sotsky explain that, despite the vexing “Lyme Wars,” there is cause for both doctors and patients to be optimistic. The past decade’s advances in precision medicine and biotechnology are reshaping our understanding of Lyme disease and accelerating the discovery of new tools to diagnose and treat it, such that the great divide previously separating medical communities is now being bridged. Drawing on both extensive clinical experience and cutting-edge research, Fallon, Sotsky, and their colleagues present these paradigm-shifting breakthroughs in language accessible to both sides. They clearly explain the immunologic, infectious, and neurologic basis of chronic symptoms, the cognitive and psychological impact of the disease, as well as current and emerging diagnostic tests, treatments, and prevention strategies. Written for the educated patient and health care provider seeking to learn more, Conquering Lyme Disease gives an up-to-the-minute overview of the science that is transforming the way we address this complex illness. It argues forcefully that the expanding plague of Lyme and other tick-borne diseases can be confronted successfully and may soon even be reversed.

Lyme disease is the most common tick-borne illness in the United States, with more than 300,000 cases diagnosed each year. However, doctors are deeply divided on how to diagnose and treat it, giving rise to the controversy known as the “Lyme Wars.” Firmly entrenched camps have emerged, causing physicians, patient communities, and insurance providers to be pitted against one another in a struggle to define Lyme disease and its clinical challenges. Health care providers may not be aware of its diverse manifestations or the limitations of diagnostic tests. Meanwhile, patients have felt dismissed by their doctors and confused by the conflicting opinions and dubious self-help information found online.

In this authoritative book, the Columbia University Medical Center physicians Brian A. Fallon and Jennifer Sotsky explain that, despite the vexing “Lyme Wars,” there is cause for both doctors and patients to be optimistic. The past decade’s advances in precision medicine and biotechnology are reshaping our understanding of Lyme disease and accelerating the discovery of new tools to diagnose and treat it, such that the great divide previously separating medical communities is now being bridged. Drawing on both extensive clinical experience and cutting-edge research, Fallon, Sotsky, and their colleagues present these paradigm-shifting breakthroughs in language accessible to both sides. They clearly explain the immunologic, infectious, and neurologic basis of chronic symptoms, the cognitive and psychological impact of the disease, as well as current and emerging diagnostic tests, treatments, and prevention strategies. Written for the educated patient and health care provider seeking to learn more, Conquering Lyme Disease gives an up-to-the-minute overview of the science that is transforming the way we address this complex illness. It argues forcefully that the expanding plague of Lyme and other tick-borne diseases can be confronted successfully and may soon even be reversed.

Human embryo research touches upon strongly felt moral convictions, and it raises such deep questions about the promise and perils of scientific progress that debate over its development has become a moral and political imperative. From in vitro fertilization to embryonic stem cell research, cloning, and gene editing, Americans have repeatedly struggled with how to define the moral status of the human embryo, whether to limit its experimental uses, and how to contend with sharply divided public moral perspectives on governing science.

Experiments in Democracy presents a history of American debates over human embryo research from the late 1960s to the present, exploring their crucial role in shaping norms, practices, and institutions of deliberation governing the ethical challenges of modern bioscience. J. Benjamin Hurlbut details how scientists, bioethicists, policymakers, and other public figures have attempted to answer a question of great consequence: how should the public reason about aspects of science and technology that effect fundamental dimensions of human life? Through a study of one of the most significant science policy controversies in the history of the United States, Experiments in Democracy paints a portrait of the complex relationship between science and democracy, and of U.S. society's evolving approaches to evaluating and governing science's most challenging breakthroughs.

Human embryo research touches upon strongly felt moral convictions, and it raises such deep questions about the promise and perils of scientific progress that debate over its development has become a moral and political imperative. From in vitro fertilization to embryonic stem cell research, cloning, and gene editing, Americans have repeatedly struggled with how to define the moral status of the human embryo, whether to limit its experimental uses, and how to contend with sharply divided public moral perspectives on governing science.

Experiments in Democracy presents a history of American debates over human embryo research from the late 1960s to the present, exploring their crucial role in shaping norms, practices, and institutions of deliberation governing the ethical challenges of modern bioscience. J. Benjamin Hurlbut details how scientists, bioethicists, policymakers, and other public figures have attempted to answer a question of great consequence: how should the public reason about aspects of science and technology that effect fundamental dimensions of human life? Through a study of one of the most significant science policy controversies in the history of the United States, Experiments in Democracy paints a portrait of the complex relationship between science and democracy, and of U.S. society's evolving approaches to evaluating and governing science's most challenging breakthroughs.

In 1916, Columbia University established the School of Dentistry (now known as the College of Dental Medicine). In 1917, the university merged the school with the newly acquired New York Post-graduate School of Dentistry and New York School of Dental Hygiene. To those working in the health sciences, the move was a powerful signal of a field on the rise. It recognized dental medicine as a key component of individual and social well-being and initiated a monumental era in medical innovation and progressive public health outcomes.

This hundred-year history shares the turbulent story of dentistry, a medical field in the making. It recounts the institutional battles and research controversies that set the terms for the development and practice of dentistry. The assimilation of the dental school into the university system was not smooth. Rivalries played out in public and in private; traditionalists fought the inclusion of a young and evolving medical approach. Once the school found its footing, the College of Dental Medicine developed rapidly, and by the end of the twentieth century, had successfully launched a series of global outreach programs that immeasurably helped impoverished and underserved communities worldwide. The school's work now includes transitioning the field into the digital age and effecting even greater change in the lives of those without access to high-quality dental care. Featuring fascinating biographical details of the school's major teachers, administrators, and graduates, this book secures the reputation of Columbia University's College of Dental Medicine as a global leader in advancing the public good.

This beautifully illustrated, elegantly written textbook pairs the best research on the biochemical properties and physiological effects of medicinal plants with a fascinating history of their use throughout human civilization, revealing the influence of nature's pharmacopeia on art, war, conquest, and law. By chronicling the ways in which humans have cultivated plant species, extracted their active chemical ingredients, and investigated their effects on the body over time, Nature's Pharmacopeia also builds an unparalleled portrait of these special herbs as they transitioned from wild flora and botanical curiosities to commodities and potent drugs.

The book opens with an overview of the use of medicinal plants in the traditional practices and indigenous belief systems of people in the Americas, Africa, Asia, and ancient Europe. It then connects medicinal plants to the growth of scientific medicine in the West. Subsequent chapters cover the regulation of drugs; the use of powerful plant chemicals—such as cocaine, nicotine, and caffeine—in various medical settings; and the application of biomedicine's intellectual frameworks to the manufacture of novel drugs from ancient treatments. Geared toward nonspecialists, this text fosters a deep appreciation of the complex chemistry and cultural resonance of herbal medicine, while suggesting how we may further tap the vast repositories of the world's herbal knowledge to create new pharmaceuticals.

This beautifully illustrated, elegantly written textbook pairs the best research on the biochemical properties and physiological effects of medicinal plants with a fascinating history of their use throughout human civilization, revealing the influence of nature's pharmacopeia on art, war, conquest, and law. By chronicling the ways in which humans have cultivated plant species, extracted their active chemical ingredients, and investigated their effects on the body over time, Nature's Pharmacopeia also builds an unparalleled portrait of these special herbs as they transitioned from wild flora and botanical curiosities to commodities and potent drugs.

The book opens with an overview of the use of medicinal plants in the traditional practices and indigenous belief systems of people in the Americas, Africa, Asia, and ancient Europe. It then connects medicinal plants to the growth of scientific medicine in the West. Subsequent chapters cover the regulation of drugs; the use of powerful plant chemicals—such as cocaine, nicotine, and caffeine—in various medical settings; and the application of biomedicine's intellectual frameworks to the manufacture of novel drugs from ancient treatments. Geared toward nonspecialists, this text fosters a deep appreciation of the complex chemistry and cultural resonance of herbal medicine, while suggesting how we may further tap the vast repositories of the world's herbal knowledge to create new pharmaceuticals.

Dickson D. Despommier's vivid, visceral account of the biology, behavior, and history of parasites follows the interplay between these fascinating life forms and human society over thousands of years. Despommier focuses on long-term host-parasite associations, which have evolved to avoid or even subvert the human immune system. Some parasites do great damage to their hosts, while others have signed a kind of "peace treaty" in exchange for their long lives within them. Many parasites also practice clever survival strategies that medical scientists hope to mimic as they search for treatments for Crohn's disease, food allergies, type 1 diabetes, organ transplantation, and other medical challenges.

Despommier concentrates on particularly remarkable and often highly pathogenic organisms, describing their lifecycles and the mechanisms they use to avoid elimination. He details their attack and survival plans and the nature of the illnesses they cause in general terms, enabling readers of all backgrounds to steal a glimpse into the secret work of such effective invaders. He also points to the cultural contexts in which these parasites thrive and reviews the current treatments available to defeat them. Encouraging scientists to continue to study these organisms even if their threat is largely contained, Despommier shows how closer dissection of the substances parasites produce to alter our response to them could help unravel some of our most complex medical conundrums.

In recent decades, we have seen five perilous and interlocking trends dominate global discourse: irreversible climate change, extreme food and water shortages, rising chronic illnesses, and rampant obesity. Why can't we make any progress in counteracting these problems despite vast expenditures of intellectual, institutional, and social capital? What makes these global emergencies the "wicked problems" that resist our best efforts and only grow more daunting?

Daniel Callahan, noted author and the nation's preeminent scholar in bioethics, examines these global problems and shines a light on the institutions, practices, and actors that block major change. We see partisan political and ideological forces, old-fashioned hucksters, and trumped-up scientific disagreements but also the problem of modern progress itself. Obesity, anthropogenic climate change, degenerative diseases, ecological degradation, and global famine are often the unintended consequences of unchecked industrial growth, insatiable eating habits, and technologically extended life spans. Only through well-crafted political, regulatory, industrial, and cultural counterstrategies can we change enough minds to check these threats. With big thinking on issues that are usually evaluated separately, this book is sure to scramble partisan divides and provoke unusual, heated debate.

Personalized healthcare—or what the award-winning author Donna Dickenson calls "Me Medicine"—is radically transforming our longstanding "one-size-fits-all" model. Technologies such as direct-to-consumer genetic testing, pharmacogenetically developed therapies in cancer care, private umbilical cord blood banking, and neurocognitive enhancement claim to cater to an individual's specific biological character, and, in some cases, these technologies have shown powerful potential. Yet in others they have produced negligible or even negative results. Whatever is behind the rise of Me Medicine, it isn't just science. So why is Me Medicine rapidly edging out We Medicine, and how has our commitment to our collective health suffered as a result?

In her cogent, provocative analysis, Dickenson examines the economic and political factors fueling the Me Medicine phenomenon and explores how, over time, this paradigm shift in how we approach our health might damage our individual and collective well-being. Historically, the measures of "We Medicine," such as vaccination and investment in public-health infrastructure, have radically extended our life spans, and Dickenson argues we've lost sight of that truth in our enthusiasm for "Me Medicine."

Dickenson explores how personalized medicine illustrates capitalism's protean capacity for creating new products and markets where none existed before—and how this, rather than scientific plausibility, goes a long way toward explaining private umbilical cord blood banks and retail genetics. Drawing on the latest findings from leading scientists, social scientists, and political analysts, she critically examines four possible hypotheses driving our Me Medicine moment: a growing sense of threat; a wave of patient narcissism; corporate interests driving new niche markets; and the dominance of personal choice as a cultural value. She concludes with insights from political theory that emphasize a conception of the commons and the steps we can take to restore its value to modern biotechnology.

Dickson D. Despommier's vivid, visceral account of the biology, behavior, and history of parasites follows the interplay between these fascinating life forms and human society over thousands of years. Despommier focuses on long-term host-parasite associations, which have evolved to avoid or even subvert the human immune system. Some parasites do great damage to their hosts, while others have signed a kind of "peace treaty" in exchange for their long lives within them. Many parasites also practice clever survival strategies that medical scientists hope to mimic as they search for treatments for Crohn's disease, food allergies, type 1 diabetes, organ transplantation, and other medical challenges.

Despommier concentrates on particularly remarkable and often highly pathogenic organisms, describing their lifecycles and the mechanisms they use to avoid elimination. He details their attack and survival plans and the nature of the illnesses they cause in general terms, enabling readers of all backgrounds to steal a glimpse into the secret work of such effective invaders. He also points to the cultural contexts in which these parasites thrive and reviews the current treatments available to defeat them. Encouraging scientists to continue to study these organisms even if their threat is largely contained, Despommier shows how closer dissection of the substances parasites produce to alter our response to them could help unravel some of our most complex medical conundrums.

Personalized healthcare—or what the award-winning author Donna Dickenson calls "Me Medicine"—is radically transforming our longstanding "one-size-fits-all" model. Technologies such as direct-to-consumer genetic testing, pharmacogenetically developed therapies in cancer care, private umbilical cord blood banking, and neurocognitive enhancement claim to cater to an individual's specific biological character, and, in some cases, these technologies have shown powerful potential. Yet in others they have produced negligible or even negative results. Whatever is behind the rise of Me Medicine, it isn't just science. So why is Me Medicine rapidly edging out We Medicine, and how has our commitment to our collective health suffered as a result?

In her cogent, provocative analysis, Dickenson examines the economic and political factors fueling the Me Medicine phenomenon and explores how, over time, this paradigm shift in how we approach our health might damage our individual and collective well-being. Historically, the measures of "We Medicine," such as vaccination and investment in public-health infrastructure, have radically extended our life spans, and Dickenson argues we've lost sight of that truth in our enthusiasm for "Me Medicine."

Dickenson explores how personalized medicine illustrates capitalism's protean capacity for creating new products and markets where none existed before—and how this, rather than scientific plausibility, goes a long way toward explaining private umbilical cord blood banks and retail genetics. Drawing on the latest findings from leading scientists, social scientists, and political analysts, she critically examines four possible hypotheses driving our Me Medicine moment: a growing sense of threat; a wave of patient narcissism; corporate interests driving new niche markets; and the dominance of personal choice as a cultural value. She concludes with insights from political theory that emphasize a conception of the commons and the steps we can take to restore its value to modern biotechnology.

Peter Piot, founding executive director of the Joint United Nations Programme on HIV/AIDS (UNAIDS), recounts his experience as a clinician, scientist, and activist fighting the disease from its earliest manifestation to today. The AIDS pandemic was not only catastrophic to the health of millions worldwide but also fractured international relations, global access to new technologies, and public health policies in nations across the globe. As he struggled to get ahead of the disease, Piot found science does little good when it operates independently of politics and economics, and politics is worthless if it rejects scientific evidence and respect for human rights.

Piot describes how the epidemic altered global attitudes toward sexuality, the character of the doctor-patient relationship, the influence of civil society in international relations, and traditional partisan divides. AIDS thrust health into national and international politics where, he argues, it rightly belongs. The global reaction to AIDS over the past decade is the positive result of this partnership, showing what can be achieved when science, politics, and policy converge on the ground. Yet it remains a fragile achievement, and Piot warns against complacency and the consequences of reduced investments. He refuses to accept a world in which high levels of HIV infection are the norm. Instead, he explains how to continue to reduce the incidence of the disease to minute levels through both prevention and treatment, until a vaccine is discovered.

Neil Krishan Aggarwal's timely study finds that mental-health and biomedical professionals have created new forms of knowledge and practice in their desire to understand and fight terrorism. In the process, the state has used psychiatrists and psychologists to furnish knowledge on undesirable populations, and psychiatrists and psychologists have protected state interests.

Professional interpretation, like all interpretations, is subject to cultural forces. Drawing on cultural psychiatry and medical anthropology, Aggarwal analyzes the transformation of definitions for normal and abnormal behavior in a vast array of sources: government documents, professional bioethical debates, legal motions and opinions, psychiatric and psychological scholarship, media publications, and policy briefs. Critical themes emerge on the use of mental health in awarding or denying disability to returning veterans, characterizing the confinement of Guantánamo detainees, contextualizing the actions of suicide bombers, portraying Muslim and Arab populations in psychiatric and psychological scholarship, illustrating bioethical issues in the treatment of detainees, and supplying the knowledge and practice to deradicalize terrorists. Throughout, Aggarwal explores this fascinating, troublesome transformation of mental-health science into a potential instrument of counterterrorism.

The health-care system in the United States is by far the most expensive in the world, yet its outcomes are decidedly mediocre in comparison with those of other countries. Poor communication between doctors and patients, Dennis Rosen argues, is at the heart of this disparity, a pervasive problem that damages the well-being of the patient and the integrity of the health-care system and society.

Drawing upon research in biomedicine, sociology, and anthropology and integrating personal stories from his medical practice in three different countries (and as a patient), Rosen shows how important good communication between physicians and patients is to high-quality—and less-expensive—care. Without it, treatment adherence and preventive services decline, and the rates of medical complications, hospital readmissions, and unnecessary testing and procedures rise. Rosen illustrates the consequences of these problems from both the caregiver and patient perspectives and explores the socioeconomic and cultural factors that cause important information to be literally lost in translation. He concludes with a prescriptive chapter aimed at building the cultural competencies and communication skills necessary for higher-quality, less-expensive care, making it more satisfying for all involved.

Two leading neuroscientists introduce the concepts of "cerebral plasticity" and the "regenerating brain," describing what we know now about the processes through which the brain constantly reconstructs itself and the potential benefits this knowledge could have in addressing concerns for neurological, cognitive, and emotional health.

The authors begin with a survey of the fundamental scientific developments that led to our current understanding of the regenerative mind, elucidating the breakthrough neurobiological studies that paved the way for our present understanding of the brain's plasticity and regenerative capabilities. They then discuss the application of these findings to such issues as depression, dyslexia, schizophrenia, and cognitive therapy, incorporating the latest technologies in neuroimaging, optogenetics, and nanotechnology. Their work shows the brain is anything but a static organ, ceasing to grow as human beings become adults. Rather, the brain is dynamic, evolving organically in relation to physical, cultural, historical, and affective stimuli, a plasticity that provides early hope to survivors of trauma and degenerative disorders.

At a ceremony announcing the completion of the first draft of the human genome in 2000, President Bill Clinton declared, "I believe one of the great truths to emerge from this triumphant expedition inside the human genome is that in genetic terms, all human beings, regardless of race, are more than 99.9 percent the same." Yet despite this declaration of unity, biomedical research has focused increasingly on mapping that.1 percent of difference, particularly as it relates to race.

This trend is exemplified by the drug BiDil. Approved by the FDA in 2005 as the first drug with a race-specific indication on its label, BiDil was originally touted as a pathbreaking therapy to treat heart failure in black patients and help underserved populations. Upon closer examination, however, Jonathan Kahn reveals a far more complex story. At the most basic level, BiDil became racial through legal maneuvering and commercial pressure as much as through medical understandings of how the drug worked.

Using BiDil as a central case study, Kahn broadly examines the legal and commercial imperatives driving the expanding role of race in biomedicine, even as scientific advances in genomics could render the issue irrelevant. He surveys the distinct politics informing the use of race in medicine and the very real health disparities caused by racism and social injustice that are now being cast as a mere function of genetic difference. Calling for a more reasoned approach to using race in biomedical research and practice, Kahn asks readers to recognize that, just as genetics is a complex field requiring sensitivity and expertise, so too is race, particularly in the field of biomedicine.

At a ceremony announcing the completion of the first draft of the human genome in 2000, President Bill Clinton declared, "I believe one of the great truths to emerge from this triumphant expedition inside the human genome is that in genetic terms, all human beings, regardless of race, are more than 99.9 percent the same." Yet despite this declaration of unity, biomedical research has focused increasingly on mapping that.1 percent of difference, particularly as it relates to race.

This trend is exemplified by the drug BiDil. Approved by the FDA in 2005 as the first drug with a race-specific indication on its label, BiDil was originally touted as a pathbreaking therapy to treat heart failure in black patients and help underserved populations. Upon closer examination, however, Jonathan Kahn reveals a far more complex story. At the most basic level, BiDil became racial through legal maneuvering and commercial pressure as much as through medical understandings of how the drug worked.

Using BiDil as a central case study, Kahn broadly examines the legal and commercial imperatives driving the expanding role of race in biomedicine, even as scientific advances in genomics could render the issue irrelevant. He surveys the distinct politics informing the use of race in medicine and the very real health disparities caused by racism and social injustice that are now being cast as a mere function of genetic difference. Calling for a more reasoned approach to using race in biomedical research and practice, Kahn asks readers to recognize that, just as genetics is a complex field requiring sensitivity and expertise, so too is race, particularly in the field of biomedicine.

This book is the principal account of epidemiology's role in the development of effective measures to identify, prevent, and treat diseases. Throughout history, epidemiologists have challenged conventional knowledge, elucidating mysteries of causality and paving the way for remedies. From the outbreak of the bubonic plague, cholera, and cancer to the search for an effective treatment of AIDS and the origins of Alzheimer's disease, epidemiological thought has been crucial in shaping our understanding of population health issues.

Alfredo Morabia's lucid retelling sheds new light on the historical triumphs of epidemiological research and allows for contemporary readers, patients, and nontechnical audiences to make sense of the immense amount of health information disseminated by the media. By drawing from both historical and contemporary sources, Morabia provides the reader with the tools to differentiate health beliefs from health knowledge. The book covers important topics, including the H1N1 swine flu epidemic, breast cancer, the effects of aspirin, and the link between cigarettes and lung cancer.

This book is the principal account of epidemiology's role in the development of effective measures to identify, prevent, and treat diseases. Throughout history, epidemiologists have challenged conventional knowledge, elucidating mysteries of causality and paving the way for remedies. From the outbreak of the bubonic plague, cholera, and cancer to the search for an effective treatment of AIDS and the origins of Alzheimer's disease, epidemiological thought has been crucial in shaping our understanding of population health issues.

Alfredo Morabia's lucid retelling sheds new light on the historical triumphs of epidemiological research and allows for contemporary readers, patients, and nontechnical audiences to make sense of the immense amount of health information disseminated by the media. By drawing from both historical and contemporary sources, Morabia provides the reader with the tools to differentiate health beliefs from health knowledge. The book covers important topics, including the H1N1 swine flu epidemic, breast cancer, the effects of aspirin, and the link between cigarettes and lung cancer.

Adrian Johnston and Catherine Malabou defy theoretical humanities' deeply-entrenched resistance to engagements with the life sciences. Rather than treat biology and its branches as hopelessly reductive and politically suspect, they view recent advances in neurobiology and its adjacent scientific fields as providing crucial catalysts to a radical rethinking of subjectivity.

Merging three distinct disciplines—European philosophy from Descartes to the present, Freudian-Lacanian psychoanalysis, and affective neuroscience—Johnston and Malabou triangulate the emotional life of affective subjects as conceptualized in philosophy and psychoanalysis with neuroscience. Their experiments yield different outcomes. Johnston finds psychoanalysis and neurobiology have the potential to enrich each other, though affective neuroscience demands a reconsideration of whether affects can be unconscious. Investigating this vexed issue has profound implications for theoretical and practical analysis, as well as philosophical understandings of the emotions.

Malabou believes scientific explorations of the brain seriously problematize established notions of affective subjectivity in Continental philosophy and Freudian-Lacanian analysis. She confronts philosophy and psychoanalysis with something neither field has seriously considered: the concept of wonder and the cold, disturbing visage of those who have been affected by disease or injury, such that they are no longer affected emotionally. At stake in this exchange are some of philosophy's most important claims concerning the relationship between the subjective mind and the objective body, the structures and dynamics of the unconscious dimensions of mental life, the role emotion plays in making us human, and the functional differences between philosophy and science.

Adrian Johnston and Catherine Malabou defy theoretical humanities' deeply-entrenched resistance to engagements with the life sciences. Rather than treat biology and its branches as hopelessly reductive and politically suspect, they view recent advances in neurobiology and its adjacent scientific fields as providing crucial catalysts to a radical rethinking of subjectivity.

Merging three distinct disciplines—European philosophy from Descartes to the present, Freudian-Lacanian psychoanalysis, and affective neuroscience—Johnston and Malabou triangulate the emotional life of affective subjects as conceptualized in philosophy and psychoanalysis with neuroscience. Their experiments yield different outcomes. Johnston finds psychoanalysis and neurobiology have the potential to enrich each other, though affective neuroscience demands a reconsideration of whether affects can be unconscious. Investigating this vexed issue has profound implications for theoretical and practical analysis, as well as philosophical understandings of the emotions.

Malabou believes scientific explorations of the brain seriously problematize established notions of affective subjectivity in Continental philosophy and Freudian-Lacanian analysis. She confronts philosophy and psychoanalysis with something neither field has seriously considered: the concept of wonder and the cold, disturbing visage of those who have been affected by disease or injury, such that they are no longer affected emotionally. At stake in this exchange are some of philosophy's most important claims concerning the relationship between the subjective mind and the objective body, the structures and dynamics of the unconscious dimensions of mental life, the role emotion plays in making us human, and the functional differences between philosophy and science.

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. In this engaging book, Brent R. Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century.

Filled with absorbing stories of breakthroughs, this book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War I led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and details the cellular and molecular barriers thwarting scientists equipped with only the tools of traditional pharmaceutical research.

Scientists such as Stockwell are now developing methods to combat these complexities—technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules—all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Cure tells a thrilling story of science, persistence, and the quest to develop a new generation of cures.

After more than fifty years of blockbuster drug development, skeptics are beginning to fear we are reaching the end of drug discovery to combat major diseases. In this engaging book, Brent R. Stockwell, a leading researcher in the exciting new science of chemical biology, describes this dilemma and the powerful techniques that may bring drug research into the twenty-first century.

Filled with absorbing stories of breakthroughs, this book begins with the scientific achievements of the twentieth century that led to today's drug innovations. We learn how the invention of mustard gas in World War I led to early anti-cancer agents and how the efforts to decode the human genome might lead to new approaches in drug design. Stockwell then turns to the seemingly incurable diseases we face today, such as Alzheimer's, many cancers, and others with no truly effective medicines, and details the cellular and molecular barriers thwarting scientists equipped with only the tools of traditional pharmaceutical research.

Scientists such as Stockwell are now developing methods to combat these complexities—technologies for constructing and testing millions of drug candidates, sophisticated computational modeling, and entirely new classes of drug molecules—all with an eye toward solving the most profound mysteries of living systems and finding cures for intractable diseases. If successful, these methods will unlock a vast terrain of untapped drug targets that could lead to a bounty of breakthrough medicines. Offering a rare, behind-the-scenes look at this cutting-edge research, The Quest for the Cure tells a thrilling story of science, persistence, and the quest to develop a new generation of cures.

Humans have eaten earth, on purpose, for more than 2,300 years. They also crave starch, ice, chalk, and other unorthodox items of food. Some even claim they are addicted and "go crazy" without these items, but why?

Sifting through extensive historical, ethnographic, and biomedical findings, Sera L. Young creates a portrait of pica, or nonfood cravings, from humans' earliest ingestions to current trends and practices. In engaging detail, she describes the substances most frequently consumed and the many methods (including the Internet) used to obtain them. She reveals how pica is remarkably prevalent (it occurs in nearly every human culture and throughout the animal kingdom), identifies its most avid partakers (pregnant women and young children), and describes the potentially healthful and harmful effects. She evaluates the many hypotheses about the causes of pica, from the fantastical to the scientific, including hunger, nutritional deficiencies, and protective capacities. Never has a book examined pica so thoroughly or accessibly, merging absorbing history with intimate case studies to illuminate an enigmatic behavior deeply entwined with human biology and culture.

Humans have eaten earth, on purpose, for more than 2,300 years. They also crave starch, ice, chalk, and other unorthodox items of food. Some even claim they are addicted and "go crazy" without these items, but why?

Sifting through extensive historical, ethnographic, and biomedical findings, Sera L. Young creates a portrait of pica, or nonfood cravings, from humans' earliest ingestions to current trends and practices. In engaging detail, she describes the substances most frequently consumed and the many methods (including the Internet) used to obtain them. She reveals how pica is remarkably prevalent (it occurs in nearly every human culture and throughout the animal kingdom), identifies its most avid partakers (pregnant women and young children), and describes the potentially healthful and harmful effects. She evaluates the many hypotheses about the causes of pica, from the fantastical to the scientific, including hunger, nutritional deficiencies, and protective capacities. Never has a book examined pica so thoroughly or accessibly, merging absorbing history with intimate case studies to illuminate an enigmatic behavior deeply entwined with human biology and culture.

The media constantly bombard us with news of health hazards lurking in our everyday lives, but many of these hazards turn out to have been greatly overblown. According to author and epidemiologist Geoffrey C. Kabat, this hyping of low-level environmental hazards leads to needless anxiety and confusion on the part of the public concerning which exposures have important effects on health and which are likely to have minimal or no effect.

Kabat approaches health scares as "social facts" and shows that a variety of factors can contribute to the inflating of a hazard. These include skewed reporting by the media, but also, surprisingly, the actions of researchers who may emphasize certain findings while ignoring others; regulatory and health agencies eager to show their responsiveness to the health concerns of the public; and politicians and advocates with a stake in a particular outcome.

By means of four case studies, Kabat demonstrates how a powerful confluence of interests can lead to overstating or distorting the scientific evidence. He considers the health risks of pollutants such as DDT as a cause of breast cancer, electromagnetic fields from power lines, radon within residences, and secondhand tobacco smoke. Tracing the trajectory of each of these hazards from its initial emergence to the present, Kabat shows how publication of more rigorous studies and critical assessments ultimately help put hazards in perspective.

The media constantly bombard us with news of health hazards lurking in our everyday lives, but many of these hazards turn out to have been greatly overblown. According to author and epidemiologist Geoffrey C. Kabat, this hyping of low-level environmental hazards leads to needless anxiety and confusion on the part of the public concerning which exposures have important effects on health and which are likely to have minimal or no effect.

Kabat approaches health scares as "social facts" and shows that a variety of factors can contribute to the inflating of a hazard. These include skewed reporting by the media, but also, surprisingly, the actions of researchers who may emphasize certain findings while ignoring others; regulatory and health agencies eager to show their responsiveness to the health concerns of the public; and politicians and advocates with a stake in a particular outcome.

By means of four case studies, Kabat demonstrates how a powerful confluence of interests can lead to overstating or distorting the scientific evidence. He considers the health risks of pollutants such as DDT as a cause of breast cancer, electromagnetic fields from power lines, radon within residences, and secondhand tobacco smoke. Tracing the trajectory of each of these hazards from its initial emergence to the present, Kabat shows how publication of more rigorous studies and critical assessments ultimately help put hazards in perspective.

States have banned smoking in workplaces, restaurants, and bars. They have increased tobacco tax rates, extended "clean air" laws, and mounted dramatic antismoking campaigns. Yet tobacco use remains high among Americans, prompting many health professionals to seek bolder measures to reduce smoking rates, which has raised concerns about the social and economic consequences of these measures.

Retail and hospitality businesses worry smoking bans and excise taxes will reduce profit, and with tobacco farming and cigarette manufacturing concentrated in southeastern states, policymakers fear the decline of regional economies. Such concerns are not necessarily unfounded, though until now, no comprehensive survey has responded to these beliefs by capturing the impact of tobacco control across the nation. This book, the result of research commissioned by Legacy and Columbia University's Institute for Social and Economic Research and Policy, considers the economic impact of reducing smoking rates on tobacco farmers, cigarette-factory workers, the southeastern regional economy, state governments, tobacco retailers, the hospitality industry, and nonprofit organizations that might benefit from the industry's philanthropy. It also measures the effect of smoking reduction on mortality rates, medical costs, and Social Security. Concluding essays consider the implications of more vigorous tobacco control policy for law enforcement, smokers who face social stigma, the mentally ill who may cope through tobacco, and disparities in health by race, social class, and gender.

States have banned smoking in workplaces, restaurants, and bars. They have increased tobacco tax rates, extended "clean air" laws, and mounted dramatic antismoking campaigns. Yet tobacco use remains high among Americans, prompting many health professionals to seek bolder measures to reduce smoking rates, which has raised concerns about the social and economic consequences of these measures.

Retail and hospitality businesses worry smoking bans and excise taxes will reduce profit, and with tobacco farming and cigarette manufacturing concentrated in southeastern states, policymakers fear the decline of regional economies. Such concerns are not necessarily unfounded, though until now, no comprehensive survey has responded to these beliefs by capturing the impact of tobacco control across the nation. This book, the result of research commissioned by Legacy and Columbia University's Institute for Social and Economic Research and Policy, considers the economic impact of reducing smoking rates on tobacco farmers, cigarette-factory workers, the southeastern regional economy, state governments, tobacco retailers, the hospitality industry, and nonprofit organizations that might benefit from the industry's philanthropy. It also measures the effect of smoking reduction on mortality rates, medical costs, and Social Security. Concluding essays consider the implications of more vigorous tobacco control policy for law enforcement, smokers who face social stigma, the mentally ill who may cope through tobacco, and disparities in health by race, social class, and gender.

If college is supposed to be the best time of our lives, why are so many students unhappy? What causes a well-adjusted and academically successful high school graduate to suddenly flounder when he reaches college? Why might she start to skip classes, binge on alcohol, or engage in unsatisfying hook-ups? Where does the anger and self-doubt come from, and why is it directed at loving parents or the student himself? Drawing on years of experience treating college-age youth, David Leibow, M.D. provides fresh, honest, and realistic answers to these and other important questions.

Instead of adventure, liberation, and a triumphant march into adulthood, many college students experience shame, regression, and social and academic failure. Yet by understanding themselves better and making reasonable changes, students can grow from these challenges and turn bad choices into wiser personal and educational decisions. Leibow focuses on issues common to college settings-anxiety and depression, drug and alcohol abuse, laziness and work avoidance, body-image problems, and unhealthy relationships-detailing coping strategies and professional resources that best respond to each crisis. His intimate knowledge of campus life and its unique challenges adds credibility and weight to his advice. Reorienting the expectations of parents and students while providing the tools for overcoming a variety of hurdles, Leibow shows how college can still become one of the best times of our lives.

Paul A. Offit and Charlotte A. Moser answer questions about the science and safety of modern vaccines. In straightforward prose, they explain how vaccines work, how they are made, and how they are tested. Most important, they separate the real risks of vaccines from feared but unfounded risks.

Offit and Moser address parental fears that children may receive too many vaccines too early, that the HPV vaccine may cause chronic fatigue or other dangerous side effects, that additives and preservatives in vaccines cause autism, and that vaccines might do more harm than good. There couldn't be a better moment or more pressing need for this book, which offers honesty—instead of hype—in the quest to protect children's health.

A London researcher was the first to assert that the combination measles-mumps-rubella vaccine known as MMR caused autism in children. Following this "discovery," a handful of parents declared that a mercury-containing preservative in several vaccines was responsible for the disease. If mercury caused autism, they reasoned, eliminating it from a child's system should treat the disorder. Consequently, a number of untested alternative therapies arose, and, most tragically, in one such treatment, a doctor injected a five-year-old autistic boy with a chemical in an effort to cleanse him of mercury, which stopped his heart instead.

Children with autism have been placed on stringent diets, subjected to high-temperature saunas, bathed in magnetic clay, asked to swallow digestive enzymes and activated charcoal, and injected with various combinations of vitamins, minerals, and acids. Instead of helping, these therapies can hurt those who are most vulnerable, and particularly in the case of autism, they undermine childhood vaccination programs that have saved millions of lives. An overwhelming body of scientific evidence clearly shows that childhood vaccines are safe and does not cause autism. Yet widespread fear of vaccines on the part of parents persists.

In this book, Paul A. Offit, a national expert on vaccines, challenges the modern-day false prophets who have so egregiously misled the public and exposes the opportunism of the lawyers, journalists, celebrities, and politicians who support them. Offit recounts the history of autism research and the exploitation of this tragic condition by advocates and zealots. He considers the manipulation of science in the popular media and the courtroom, and he explores why society is susceptible to the bad science and risky therapies put forward by many antivaccination activists.

If college is supposed to be the best time of our lives, why are so many students unhappy? What causes a well-adjusted and academically successful high school graduate to suddenly flounder when he reaches college? Why might she start to skip classes, binge on alcohol, or engage in unsatisfying hook-ups? Where does the anger and self-doubt come from, and why is it directed at loving parents or the student himself? Drawing on years of experience treating college-age youth, David Leibow, M.D. provides fresh, honest, and realistic answers to these and other important questions.

Instead of adventure, liberation, and a triumphant march into adulthood, many college students experience shame, regression, and social and academic failure. Yet by understanding themselves better and making reasonable changes, students can grow from these challenges and turn bad choices into wiser personal and educational decisions. Leibow focuses on issues common to college settings-anxiety and depression, drug and alcohol abuse, laziness and work avoidance, body-image problems, and unhealthy relationships-detailing coping strategies and professional resources that best respond to each crisis. His intimate knowledge of campus life and its unique challenges adds credibility and weight to his advice. Reorienting the expectations of parents and students while providing the tools for overcoming a variety of hurdles, Leibow shows how college can still become one of the best times of our lives.

A London researcher was the first to assert that the combination measles-mumps-rubella vaccine known as MMR caused autism in children. Following this "discovery," a handful of parents declared that a mercury-containing preservative in several vaccines was responsible for the disease. If mercury caused autism, they reasoned, eliminating it from a child's system should treat the disorder. Consequently, a number of untested alternative therapies arose, and, most tragically, in one such treatment, a doctor injected a five-year-old autistic boy with a chemical in an effort to cleanse him of mercury, which stopped his heart instead.

Children with autism have been placed on stringent diets, subjected to high-temperature saunas, bathed in magnetic clay, asked to swallow digestive enzymes and activated charcoal, and injected with various combinations of vitamins, minerals, and acids. Instead of helping, these therapies can hurt those who are most vulnerable, and particularly in the case of autism, they undermine childhood vaccination programs that have saved millions of lives. An overwhelming body of scientific evidence clearly shows that childhood vaccines are safe and does not cause autism. Yet widespread fear of vaccines on the part of parents persists.

In this book, Paul A. Offit, a national expert on vaccines, challenges the modern-day false prophets who have so egregiously misled the public and exposes the opportunism of the lawyers, journalists, celebrities, and politicians who support them. Offit recounts the history of autism research and the exploitation of this tragic condition by advocates and zealots. He considers the manipulation of science in the popular media and the courtroom, and he explores why society is susceptible to the bad science and risky therapies put forward by many antivaccination activists.

Science has long treated religion as a set of personal beliefs that have little to do with a rational understanding of the mind and the universe. However, B. Alan Wallace, a respected Buddhist scholar, proposes that the contemplative methodologies of Buddhism and of Western science are capable of being integrated into a single discipline: contemplative science.

The science of consciousness introduces first-person methods of investigating the mind through Buddhist contemplative techniques, such as samatha, an organized, detailed system of training the attention. Just as scientists make observations and conduct experiments with the aid of technology, contemplatives have long tested their own theories with the help of highly developed meditative skills of observation and experimentation. Contemplative science allows for a deeper knowledge of mental phenomena, including a wide range of states of consciousness, and its emphasis on strict mental discipline counteracts the effects of conative (intention and desire), attentional, cognitive, and affective imbalances.

Just as behaviorism, psychology, and neuroscience have all shed light on the cognitive processes that enable us to survive and flourish, contemplative science offers a groundbreaking perspective for expanding our capacity to realize genuine well-being. It also forges a link between the material world and the realm of the subconscious that transcends the traditional science-based understanding of the self.

Science has long treated religion as a set of personal beliefs that have little to do with a rational understanding of the mind and the universe. However, B. Alan Wallace, a respected Buddhist scholar, proposes that the contemplative methodologies of Buddhism and of Western science are capable of being integrated into a single discipline: contemplative science.

The science of consciousness introduces first-person methods of investigating the mind through Buddhist contemplative techniques, such as samatha, an organized, detailed system of training the attention. Just as scientists make observations and conduct experiments with the aid of technology, contemplatives have long tested their own theories with the help of highly developed meditative skills of observation and experimentation. Contemplative science allows for a deeper knowledge of mental phenomena, including a wide range of states of consciousness, and its emphasis on strict mental discipline counteracts the effects of conative (intention and desire), attentional, cognitive, and affective imbalances.

Just as behaviorism, psychology, and neuroscience have all shed light on the cognitive processes that enable us to survive and flourish, contemplative science offers a groundbreaking perspective for expanding our capacity to realize genuine well-being. It also forges a link between the material world and the realm of the subconscious that transcends the traditional science-based understanding of the self.

In recent years, new disease threats—such as SARS, avian flu, mad cow disease, and drug-resistant strains of malaria and tuberculosis—have garnered media attention and galvanized political response. Proposals for new approaches to "securing health" against these threats have come not only from public health and medicine but also from such fields as emergency management, national security, and global humanitarianism.

This volume provides a map of this complex and rapidly transforming terrain. The editors focus on how experts, public officials, and health practitioners work to define what it means to "secure health" through concrete practices such as global humanitarian logistics, pandemic preparedness measures, vaccination campaigns, and attempts to regulate potentially dangerous new biotechnologies.

As the contributions show, despite impressive activity in these areas, the field of "biosecurity interventions" remains unstable. Many basic questions are only beginning to be addressed: Who decides what counts as a biosecurity problem? Who is responsible for taking action, and how is the efficacy of a given intervention to be evaluated? It is crucial to address such questions today, when responses to new problems of health and security are still taking shape. In this context, this volume offers a form of critical and reflexive knowledge that examines how technical efforts to increase biosecurity relate to the political and ethical challenges of living with risk.

The increase in environmentally induced diseases and the loosening of regulation and safety measures have inspired a massive challenge to established ways of looking at health and the environment. Communities with disease clusters, women facing a growing breast cancer incidence rate, and people of color concerned about the asthma epidemic have become critical of biomedical models that emphasize the role of genetic makeup and individual lifestyle practices. Likewise, scientists have lost patience with their colleagues' and government's failure to adequately address environmental health issues and to safeguard research from corporate manipulation.

Focusing specifically on breast cancer, asthma, and Gulf War-related health conditions-"contested illnesses" that have generated intense debate in the medical and political communities-Phil Brown shows how these concerns have launched an environmental health movement that has revolutionized scientific thinking and policy. Before the last three decades of widespread activism regarding toxic exposures, people had little opportunity to get information. Few sympathetic professionals were available, the scientific knowledge base was weak, government agencies were largely unprepared, laypeople were not considered bearers of useful knowledge, and ordinary people lacked their own resources for discovery and action.

Brown argues that organized social movements are crucial in recognizing and acting to combat environmental diseases. His book draws on environmental and medical sociology, environmental justice, environmental health science, and social movement studies to show how citizen-science alliances have fought to overturn dominant epidemiological paradigms. His probing look at the ways scientific findings are made available to the public and the changing nature of policy offers a new perspective on health and the environment and the relationship among people, knowledge, power, and authority.

Most of us remember where we were and what we were doing on September 11, 2001. Why do most experiences leave little trace while some—even terrible ordeals that people wish they could forget—leave memories that last a lifetime? That is the mystery at the heart of this book.

Drawing on fascinating research and case studies, James McGaugh, a distinguished neuroscientist, reveals that the key to understanding how memories are created may well be understanding how they are lost. He shows that lasting memories are not stored instantly. Why the delay? The author explains how the slow consolidation of memory has important adaptive consequences. It allows physiological processes activated by experiences to regulate the strength of the memory of the experiences. Emotionally arousing experiences induce the release of stress hormones, which act on the brain to influence the consolidation of our memories of recent experience. These findings have important implications for the controversial issues of post–traumatic stress disorder and repressed memory syndrome.

From the prescientific writings of William James to the animal studies of the memory-research pioneers Pavlov, Thorndike, and Tolman, to the latest research of psychologists and neurologists drawing on PET imaging studies of the brain and laboratory experiments involving a variety of drugs, this succinct book provides a wealth of information.

By tracking the distribution of disease and pinpointing relevant risk factors, social epidemiology reveals how social problems are intrinsically linked to the health of populations. The practice also takes into account the psychosocial, biological, and medical determinants of disease and health, encouraging a rich and multidisciplinary approach to analyzing and solving complex contemporary social issues.

This book provides a clear and comprehensive set of tools for practice. Julie Cwikel begins with an overview of the historical roots of public health and social medicine and shows how they formed the theoretical basis for current social epidemiological methods. Cwikel then explains the theoretical and programmatic tools social epidemiologists use in their research, program planning, and evaluation. In conclusion, Cwikel demonstrates how the SOCEPID model can be applied to a range of topics, including chronic illness, obesity, violence prevention, occupational health, sexually transmitted diseases (especially HIV), environmental hazards, and addressing the needs of vulnerable populations such as immigrants and trafficked women.

With compelling authority, Cwikel shows readers how the exciting and growing field of social epidemiology is both practical and activist, drawing on cutting-edge empirical findings to conduct policymaking research and promote health at both the personal and population levels.

Most of us remember where we were and what we were doing on September 11, 2001. Why do most experiences leave little trace while some—even terrible ordeals that people wish they could forget—leave memories that last a lifetime? That is the mystery at the heart of this book.

Drawing on fascinating research and case studies, James McGaugh, a distinguished neuroscientist, reveals that the key to understanding how memories are created may well be understanding how they are lost. He shows that lasting memories are not stored instantly. Why the delay? The author explains how the slow consolidation of memory has important adaptive consequences. It allows physiological processes activated by experiences to regulate the strength of the memory of the experiences. Emotionally arousing experiences induce the release of stress hormones, which act on the brain to influence the consolidation of our memories of recent experience. These findings have important implications for the controversial issues of post–traumatic stress disorder and repressed memory syndrome.

From the prescientific writings of William James to the animal studies of the memory-research pioneers Pavlov, Thorndike, and Tolman, to the latest research of psychologists and neurologists drawing on PET imaging studies of the brain and laboratory experiments involving a variety of drugs, this succinct book provides a wealth of information.

Why do smokers claim that the first cigarette of the day is the best? What is the biological basis behind some heavy drinkers' belief that the "hair-of-the-dog" method alleviates the effects of a hangover? Why does marijuana seem to affect ones problem-solving capacity? Intoxicating Minds is, in the author's words, "a grand excavation of drug myth." Neither extolling nor condemning drug use, it is a story of scientific and artistic achievement, war and greed, empires and religions, and lessons for the future.

Ciaran Regan looks at each class of drugs, describing the historical evolution of their use, explaining how they work within the brain's neurophysiology, and outlining the basic pharmacology of those substances. From a consideration of the effect of stimulants, such as caffeine and nicotine, and the reasons and consequences of their sudden popularity in the seventeenth century, the book moves to a discussion of more modern stimulants, such as cocaine and ecstasy. In addition, Regan explains how we process memory, the nature of thought disorders, and therapies for treating depression and schizophrenia. Regan then considers psychedelic drugs and their perceived mystical properties and traces the history of placebos to ancient civilizations. Finally, Intoxicating Minds considers the physical consequences of our co-evolution with drugs—how they have altered our very being—and offers a glimpse of the brave new world of drug therapies.

Why do smokers claim that the first cigarette of the day is the best? What is the biological basis behind some heavy drinkers' belief that the "hair-of-the-dog" method alleviates the effects of a hangover? Why does marijuana seem to affect ones problem-solving capacity? Intoxicating Minds is, in the author's words, "a grand excavation of drug myth." Neither extolling nor condemning drug use, it is a story of scientific and artistic achievement, war and greed, empires and religions, and lessons for the future.

Ciaran Regan looks at each class of drugs, describing the historical evolution of their use, explaining how they work within the brain's neurophysiology, and outlining the basic pharmacology of those substances. From a consideration of the effect of stimulants, such as caffeine and nicotine, and the reasons and consequences of their sudden popularity in the seventeenth century, the book moves to a discussion of more modern stimulants, such as cocaine and ecstasy. In addition, Regan explains how we process memory, the nature of thought disorders, and therapies for treating depression and schizophrenia. Regan then considers psychedelic drugs and their perceived mystical properties and traces the history of placebos to ancient civilizations. Finally, Intoxicating Minds considers the physical consequences of our co-evolution with drugs—how they have altered our very being—and offers a glimpse of the brave new world of drug therapies.

Why do some people still choose psychoanalysis-Freud's so-called talking cure-when numerous medications are available that treat the symptoms of psychic distress so much faster? Elisabeth Roudinesco tackles this difficult question, exploring what she sees as a "depressive society": an epidemic of distress addressed only by an increasing reliance on prescription drugs.

Far from contesting the efficacy of new medications like Prozac, Zoloft, and Viagra in alleviating the symptoms of any number of mental or nervous conditions, Roudinesco argues that the use of such drugs fails to solve patients' real problems. In the man who takes Viagra without ever wondering why he is suffering from impotence and the woman who is given antidepressants to deal with the loss of a loved one, Roudinesco sees a society obsessed with efficiency and desperate for the quick fix.

She argues that "the talking cure" and pharmacology represent not just different approaches to psychiatry, but different worldviews. The rush to treat symptoms is itself symptomatic of an antiseptic and depressive culture in which thought is reduced to the firing of neurons and desire is just a chemical secretion. In contrast, psychoanalysis testifies to human freedom and the power of language.

Why do some people still choose psychoanalysis-Freud's so-called talking cure-when numerous medications are available that treat the symptoms of psychic distress so much faster? Elisabeth Roudinesco tackles this difficult question, exploring what she sees as a "depressive society": an epidemic of distress addressed only by an increasing reliance on prescription drugs.

Far from contesting the efficacy of new medications like Prozac, Zoloft, and Viagra in alleviating the symptoms of any number of mental or nervous conditions, Roudinesco argues that the use of such drugs fails to solve patients' real problems. In the man who takes Viagra without ever wondering why he is suffering from impotence and the woman who is given antidepressants to deal with the loss of a loved one, Roudinesco sees a society obsessed with efficiency and desperate for the quick fix.

She argues that "the talking cure" and pharmacology represent not just different approaches to psychiatry, but different worldviews. The rush to treat symptoms is itself symptomatic of an antiseptic and depressive culture in which thought is reduced to the firing of neurons and desire is just a chemical secretion. In contrast, psychoanalysis testifies to human freedom and the power of language.

Igor Aleksander heads a major British team that has applied engineering principles to the understanding of the human brain and has built several pioneering machines, culminating in MAGNUS, which he calls a machine with imagination. When he asks it (in words) to produce an image of a banana that is blue with red spots, the image appears on the screen in seconds.

The idea of such an apparently imaginative, even conscious machine seems heretical and its advocates are often accused of sensationalism, arrogance, or philosophical ignorance. Part of the problem, according to Aleksander, is that consciousness remains ill-defined.

Interweaving anecdotes from his own life and research with imagined dialogues between historical figures—including Descartes, Locke, Hume, Kant, Wittgenstein, Francis Crick, and Steven Pinker—Aleksander leads readers toward an understanding of consciousness. He shows not only how the latest work with artificial neural systems suggests that an artificial form of consciousness is possible but also that its design would clarify many of the puzzles surrounding the murky concept of consciousness itself. The book also looks at the presentation of "self" in robots, the learning of language, and the nature of emotion, will, instinct, and feelings.

Memory enables us to make experience meaningful and to form coherent identities for ourselves and intelligible perceptions of others. Indeed, our ability to imagine, anticipate, and create the future is directly commensurate with our ability to retrieve and recollect past experiences.

But for all its vital importance in human cognition, for all that it seems so ordinary and obvious, memory remains in many ways as complex and mysterious today as it seemed to ancient philosophers. We need only to think about the "tip-of-the-tongue" experience to wonder how memories are formed, where they reside in our brains, and why some are retained, while others are forgotten. What is the difference between long- and short-term memory? Can memory be strengthened? Memories Are Made of This is an account of current memory science that offers answers to these and a host of other questions, comprehensively distilling much diverse and

rigorous science. It delves into the biology of memory functions and researches into the

mechanics and genetics of memory and the importance of emotions, particularly those resulting from trauma, in the memory process. Of special focus are investigations of cognition in other species. Are we the only animals who remember and forget? If not, are there commonalties in the memories of different species? The book also surveys our understanding of the effects of injury and disease on memory and concludes with an assessment of emerging pharmacological efforts to preserve and protect our memories and, in turn, ourselves.

Why do some people remain alert and vigorous at an age when others are declining mentally and physically? Does their apparent advantage have a biological basis, and, if so, could this success be transferred to others predisposed to age more quickly? If this is achievable, does brain aging then become the last obstacle to an extension of our useful life span?

These are just some of the questions answered in this fascinating book by Lawrence Whalley, a researcher who specializes in the study of Alzheimer's disease. He relates that the brain may be able to compensate for its own aging since the loss of brain cells with age is not as extensive as once believed and that, if some surviving cells retain the capacity to replicate, there may be real prospects of reducing the worst effects of brain aging.

In surveying the prospects of slowing or even preventing the worst effects of aging, Whalley looks at the development of the brain and how this is influenced by environmental factors such as diet and stress, the biological and psychological mechanisms of brain injury and disease, and the range of possible treatments and preventative measures, including gene therapy, silicon-neuron implants, virtual reality, and "intelligent environments." Throughout the book he relates the known facts about brain aging, as well as our many preconceptions. Reexamining older scientific studies, the author is able to show that though much of what we take for granted about the mental processes of the older person is not simple, we may indeed be able to alleviate the effects of mental deterioration--if not now, then in the future.

Igor Aleksander heads a major British team that has applied engineering principles to the understanding of the human brain and has built several pioneering machines, culminating in MAGNUS, which he calls a machine with imagination. When he asks it (in words) to produce an image of a banana that is blue with red spots, the image appears on the screen in seconds.

The idea of such an apparently imaginative, even conscious machine seems heretical and its advocates are often accused of sensationalism, arrogance, or philosophical ignorance. Part of the problem, according to Aleksander, is that consciousness remains ill-defined.

Interweaving anecdotes from his own life and research with imagined dialogues between historical figures—including Descartes, Locke, Hume, Kant, Wittgenstein, Francis Crick, and Steven Pinker—Aleksander leads readers toward an understanding of consciousness. He shows not only how the latest work with artificial neural systems suggests that an artificial form of consciousness is possible but also that its design would clarify many of the puzzles surrounding the murky concept of consciousness itself. The book also looks at the presentation of "self" in robots, the learning of language, and the nature of emotion, will, instinct, and feelings.

Why do some people remain alert and vigorous at an age when others are declining mentally and physically? Does their apparent advantage have a biological basis, and, if so, could this success be transferred to others predisposed to age more quickly? If this is achievable, does brain aging then become the last obstacle to an extension of our useful life span?

These are just some of the questions answered in this fascinating book by Lawrence Whalley, a researcher who specializes in the study of Alzheimer's disease. He relates that the brain may be able to compensate for its own aging since the loss of brain cells with age is not as extensive as once believed and that, if some surviving cells retain the capacity to replicate, there may be real prospects of reducing the worst effects of brain aging.

In surveying the prospects of slowing or even preventing the worst effects of aging, Whalley looks at the development of the brain and how this is influenced by environmental factors such as diet and stress, the biological and psychological mechanisms of brain injury and disease, and the range of possible treatments and preventative measures, including gene therapy, silicon-neuron implants, virtual reality, and "intelligent environments." Throughout the book he relates the known facts about brain aging, as well as our many preconceptions. Reexamining older scientific studies, the author is able to show that though much of what we take for granted about the mental processes of the older person is not simple, we may indeed be able to alleviate the effects of mental deterioration--if not now, then in the future.

Pain is one of medicine's greatest mysteries. When farmer John Mitson caught his hand in a baler, he cut off his trapped hand and carried it to a neighbor. "Sheer survival and logic" was how he described it. "And strangely, I didn't feel any pain." How can this be? We're taught that pain is a warning message to be heeded at all costs, yet it can switch off in the most agonizing circumstances or switch on for no apparent reason. Many scientists, philosophers, and laypeople imagine pain to operate like a rigid, simple signaling system, as if a particular injury generates a fixed amount of pain that simply gets transmitted to the brain; yet this mechanistic model is woefully lacking in the face of the surprising facts about what people and animals do and experience when their bodies are damaged.

Patrick Wall looks at these questions and sets his scientific account in a broad context, interweaving it with a wealth of fascinating and sometimes disturbing historical detail, such as famous characters who derived pleasure from pain, the unexpected reactions of injured people, the role of endorphins, and the power of placebo. He covers cures of pain, ranging from drugs and surgery, through relaxation techniques and exercise, to acupuncture, electrical nerve stimulation, and herbalism.

Pain involves our state of mind, our social mores and beliefs, and our personal experiences and expectations. Stepping beyond the famous neurologic gate-control theory for which he is known, Wall shows that pain is a matter of behavior and its manifestation differs among individuals, situations, and cultures. "The way we deal with pain is an expression of individuality."

What do we mean when we describe a person as intelligent? The concept of intelligence wields a powerful influence on research dealing with the brain and on how individuals progress in society. Yet, remarkably, there is no scientific consensus about the meaning of intelligence. In The Making of Intelligence Ken Richardson looks at how intelligence has been characterized and measured in the past, explores current trends in our understanding and uses of the concept, and predicts what form these trends will take in the future.

He argues that intelligence is not solely predetermined by such factors as genes and environment; it is also created by self-organizing interactions within evolved developmental systems. Considering the implications for society of this dynamic-systems approach, Richardson predicts that as our understanding of the relationship between the mind and the brain improves, the notion of intelligence as a single concept may disappear altogether.

Richardson takes particularly sharp aim at IQ tests, exposing the reductionist, oversimplified, and contradictory notions of intelligence that they presuppose as well as the social repercussions of the widespread, unreflecting acceptance of the IQ model in public consciousness.

From the writings of Charles Darwin and Herbert Spencer on evolution and adaptation to the reflections of Jean Piaget and Lev Vygotsky on logical reasoning; from the formulation of early IQ tests by Francis Binet and Henri Simon to their recent, provocative rebirth in the assertions of The Bell Curve by Charles Murray and Richard Herrnstein, The Making of Intelligence is a lucid, judicious, critical analysis of this controversial and important subject.

How much of sexual diversity is the result of nature versus nurture? Prevailing theories today lean heavily toward nature. Now a leading researcher in neuroscience and animal behavior shows how, in recent history, scientific claims about sex and gender differences have reflected the culture of the time. Although the conviction that genetics can explain everything is now widespread, the author demonstrates the interaction of culture and environment in the formation of behavioral traits and so provides an important corrective to popular notions of reductionism.

Starting with a summary of sex and gender studies, Rogers explains the error of sex biasing, especially the once-assumed inferiority of women. She then addresses several modern studies and investigations, some of which assert that sex and gender differences are the product of genetic inheritance and hormones. Rogers uses laboratory evidence from studies of animals that help illustrate the biologically fluid properties of sex and gender.

Sexing the Brain addresses a variety of topical questions: Are there sex differences in how we think and feel? Is language processed in different parts of the brain in men and women? Do social influences have a stronger influence on sexual behavior than sex hormone levels? Rogers concludes that "our biology does not bind us to remain the same.... We have the ability to change, and the future of sex differences belongs to us."

Pain is one of medicine's greatest mysteries. When farmer John Mitson caught his hand in a baler, he cut off his trapped hand and carried it to a neighbor. "Sheer survival and logic" was how he described it. "And strangely, I didn't feel any pain." How can this be? We're taught that pain is a warning message to be heeded at all costs, yet it can switch off in the most agonizing circumstances or switch on for no apparent reason. Many scientists, philosophers, and laypeople imagine pain to operate like a rigid, simple signaling system, as if a particular injury generates a fixed amount of pain that simply gets transmitted to the brain; yet this mechanistic model is woefully lacking in the face of the surprising facts about what people and animals do and experience when their bodies are damaged.

Patrick Wall looks at these questions and sets his scientific account in a broad context, interweaving it with a wealth of fascinating and sometimes disturbing historical detail, such as famous characters who derived pleasure from pain, the unexpected reactions of injured people, the role of endorphins, and the power of placebo. He covers cures of pain, ranging from drugs and surgery, through relaxation techniques and exercise, to acupuncture, electrical nerve stimulation, and herbalism.

Pain involves our state of mind, our social mores and beliefs, and our personal experiences and expectations. Stepping beyond the famous neurologic gate-control theory for which he is known, Wall shows that pain is a matter of behavior and its manifestation differs among individuals, situations, and cultures. "The way we deal with pain is an expression of individuality."

What do we mean when we describe a person as intelligent? The concept of intelligence wields a powerful influence on research dealing with the brain and on how individuals progress in society. Yet, remarkably, there is no scientific consensus about the meaning of intelligence. In The Making of Intelligence Ken Richardson looks at how intelligence has been characterized and measured in the past, explores current trends in our understanding and uses of the concept, and predicts what form these trends will take in the future.

He argues that intelligence is not solely predetermined by such factors as genes and environment; it is also created by self-organizing interactions within evolved developmental systems. Considering the implications for society of this dynamic-systems approach, Richardson predicts that as our understanding of the relationship between the mind and the brain improves, the notion of intelligence as a single concept may disappear altogether.

Richardson takes particularly sharp aim at IQ tests, exposing the reductionist, oversimplified, and contradictory notions of intelligence that they presuppose as well as the social repercussions of the widespread, unreflecting acceptance of the IQ model in public consciousness.

From the writings of Charles Darwin and Herbert Spencer on evolution and adaptation to the reflections of Jean Piaget and Lev Vygotsky on logical reasoning; from the formulation of early IQ tests by Francis Binet and Henri Simon to their recent, provocative rebirth in the assertions of The Bell Curve by Charles Murray and Richard Herrnstein, The Making of Intelligence is a lucid, judicious, critical analysis of this controversial and important subject.

Do defective genes give rise to defective thought? The revolution in molecular genetics has indeed given rise to the increasing optimism that advancements in biotechnology will soon uncover the causes of all disturbances of mind and behavior. In this book, leading psychiatrist Julian Leff counters this reductionist claim and emphasizes what is known about the psychological, social, and cultural factors underlying mental illness. In doing so, he addresses many serious and urgent questions. What exactly is the difference between sadness and depression? What are the difficulties in categorizing psychiatric conditions? How are psychiatric diagnoses made in the first place? Are international attempts to standardize diagnosis flawed? Can doctors ever hope to disentangle cause and effect in the treatment of mental illness? What is the influence of emotional relationships on psychiatric conditions? How do public attitudes to mental illness affect choices of treatment? And, finally, what does all this tell us about the cultural causes of mental illness?

Throughout the book Leff also takes stock of the origins and effects of many medications used to treat mental illnesses, from antidepressants such as Prozac to Thorazine, a drug used to treat patients with delusions and hallucinations. Showing how broad social and community forces play into human development, he highlights the importance of life events and external forces in the origin and treatment of depression and schizophrenia. Leff acknowledges the biological basis of mental activity, but underscores the vital role of the social environment.

The Unbalanced Mind addresses such questions as:

* Why was there a lower rate of diagnosis of schizophrenia in Great Britain than in the United States?

* Why do people with schizophrenia in developing countries have a better rate of recovery?

* How did the USSR use the diagnosis of schizophrenia for political ends?

Full of engaging examples, The Unbalanced Mind provides a clear picture of how mental illnesses are diagnosed and treated—and what is at the root of the cause. As Leff explains, "My vision for the future of psychiatry is one that depends not on technical advances in making images of the brain or replacing bad genes with good ones, but on increasing our understanding of relationships between people."

I think, therefore I am. The legendary pronouncement of philosopher René Descartes lingers as accepted wisdom in the Western world nearly four centuries after its author's death. But does thought really come first? Who actually runs the show: we, our thoughts, or the neurons firing within our brains?

Walter J. Freeman explores how we control our behavior and make sense of the world around us. Avoiding determinism both in sociobiology, which proposes that persons' genes control their brains' functioning, and in neuroscience, which posits that their brains' disposition is molded by chemistry and environmental forces, Freeman charts a new course—one that gives individuals due credit and responsibility for their actions.

Drawing upon his five decades of research in neuroscience, Freeman utilizes the latest advances in his field as well as perspectives from disciplines as diverse as mathematics, psychology, and philosophy to explicate how different human brains act in their chosen diverse ways. He clarifies the implications of brain imaging, by which neural activity can be observed during the course of normal movements, and shows how nonlinear dynamics reveals order within the fecund chaos of brain function.

This provocative and illuminating book charts the persistence of a cultural phenomenon. Tales of alien abduction, chronic fatigue syndrome, Gulf War syndrome, and the resurgence of repressed memories in psychotherapy are just a few of the signs that we live in an age of hysterical epidemics.

As Elaine Showalter demonstrates, the triumphs of the therapeutic society have not been able to prevent the appearance of hysterical disorders, imaginary illnesses, rumor panics, and pseudomemories that mark the end of the millenium.

Like the witch-hunts of the 1690s and the hypnotic cures of the 1980s, the hysterical syndromes of the 1990s reflect the fears and anxieties of a culture on the edge of change. Showalter highlights the full range of contemporary syndromes and draws connections to earlier times and settings, showing that hysterias mutate and are renamed; under the right circumstances, everyone is susceptible.

Today, hysterical epidemics are not spread by viruses or vapors but by stories, narratives Showalter calls hystories that are created "in the interaction of troubled patients and sympathetic therapists... circulated through self-help books, articles in newspapers and magazines, TV talk shows, popular films, the Internet, even literary criticism." Though popular stereotypes of hysteria are still stigmatizing, largely because of their associations with women, many of the most recent manifestations receive respectful and widespread coverage. In an age skeptical of Freud and the power of unconscious desires and conflicts, personal troubles are blamed on everything from devil-worshipping sadists to conspiring governments. The result is the potential for paranoia and ignorance on a massive scale.

Skillfully surveying the condition of hysteria—its causes, cures, famous patients, and doctors—in the twentieth century, Showalter also looks at literature, drama, and feminist representations of the hysterical. Hysterias, she shows, are always with us, a kind of collective coping mechanism for changing times; all that differs are names and labels, and at times of crisis, individual hysterias can become contagious.

Insightful and sensitive, filled with fascinating new perspectives on a culture saturated with syndromes of every sort, Hystories is a gift of good sense from one of our best critics.

The human brain is the most complex object in the known universe. The field of neuroscience has made remarkable strides in recent years in understanding aspects of the brain, yet we still struggle with seemingly fundamental questions about how the brain works. What lessons can we learn from neuroscience’s successes and failures? What kinds of questions can neuroscience answer, and what will remain out of reach?

In The Brain in Context, the bioethicist Jonathan D. Moreno and the neuroscientist Jay Schulkin provide an accessible and thought-provoking account of the evolution of neuroscience and the neuroscience of evolution. They emphasize that the brain is not an isolated organ—it extends into every part of the body and every aspect of human life. Understanding the brain requires studying the environmental, biological, chemical, genetic, and social factors that continue to shape it. Moreno and Schulkin describe today’s transformative devices, theories, and methods, including technologies like fMRI and optogenetics as well as massive whole-brain activity maps and the attempt to create a digital simulation of the brain. They show how theorizing about the brain and experimenting with it often go hand in hand, and they raise cautions about unintended consequences of technological interventions. The Brain in Context is a stimulating and even-handed assessment of the scope and limits of what we know about how we think.

A tiny mutation on the X chromosome can shape a family’s history. Passed down from a “carrier” parent to a child, fragile X syndrome is the most common inherited cause of intellectual disability and autism. Beyond that—and a rarity among genetic disorders—some fragile X carriers not only transmit the mutation but also experience related conditions themselves. In such cases, carriers can have tremors, infertility, and psychiatric disorders that complicate raising children with fragile X syndrome—and all too often, they suffer in silence.

The Carriers investigates this common but still little-known genetic condition and its life-altering consequences. Anne Skomorowsky reveals how this disorder afflicts families across generations, telling the stories of the mothers and grandparents of fragile X patients and considering how genes interact with family dynamics. She interweaves the personal narratives and family histories of the people affected by fragile X disorders with clear and accessible explanations of the science behind them. Skomorowsky unpacks the latest research on the fragile X mutation and explores the history of its discovery. She highlights the roles of women as carriers, caregivers, and researchers who have made astonishing scientific breakthroughs over the last three decades.

The Carriers is an essential book for fragile X families, including those just learning they are carriers, and for all readers interested in the complexities of heredity, the ethical dilemmas of genetic medicine, and the relationship between genes and personality.

What is the likelihood that common chemicals such as bisphenol-A, which is found in plastic water bottles, are harming us? Should shoppers be concerned about pesticide residues on fruits and vegetables in the supermarket produce aisle? Are we risking adverse health effects when we use insect repellent that contains DEET or slather on sunscreen? Modern life requires us to navigate an endless sea of chemicals. How do we know whether we need to worry about them?

This book is a layperson’s guide to understanding chemical risk. The toxicologist Gerald A. LeBlanc offers a nontechnical overview of the key factors in evaluating whether exposure to chemicals in our daily lives could be harmful. He leads readers through the basic concepts of risk assessment using real-world examples. LeBlanc emphasizes that chemical hazard depends on the level of exposure and provides practical strategies for sensible decision making. The book features a series of accessible case studies describing how we all can reach rational conclusions about the danger of typical chemical exposures we experience every day.

Giving nonexpert readers the tools to understand chemical risks, this book shows how critical thinking and science literacy can help us live with less fear and anxiety and make reasonable choices when confronted with potential hazards.

What is the likelihood that common chemicals such as bisphenol-A, which is found in plastic water bottles, are harming us? Should shoppers be concerned about pesticide residues on fruits and vegetables in the supermarket produce aisle? Are we risking adverse health effects when we use insect repellent that contains DEET or slather on sunscreen? Modern life requires us to navigate an endless sea of chemicals. How do we know whether we need to worry about them?

This book is a layperson’s guide to understanding chemical risk. The toxicologist Gerald A. LeBlanc offers a nontechnical overview of the key factors in evaluating whether exposure to chemicals in our daily lives could be harmful. He leads readers through the basic concepts of risk assessment using real-world examples. LeBlanc emphasizes that chemical hazard depends on the level of exposure and provides practical strategies for sensible decision making. The book features a series of accessible case studies describing how we all can reach rational conclusions about the danger of typical chemical exposures we experience every day.

Giving nonexpert readers the tools to understand chemical risks, this book shows how critical thinking and science literacy can help us live with less fear and anxiety and make reasonable choices when confronted with potential hazards.

Winner, 2023 Choice Outstanding Academic Title

Over the past several decades, psychiatry has undergone radical changes. After its midcentury heyday, psychoanalysis gave way to a worldview guided by the Diagnostic and Statistical Manual, which precisely defined mental disorders and their treatments; more recently, this too has been displaced by a model inspired by neuroscience. Each of these three dominant models overturned the previous era’s assumptions, methods, treatment options, and goals. Each has its own definitions of health and disease, its own concepts of the mind. And each has offered clinicians and patients new possibilities as well as pitfalls.

The Couch, the Clinic, and the Scanner is an insightful first-person account of psychiatry’s evolution. David Hellerstein—a psychiatrist who has practiced in New York City since the early 1980s, working with patients, doing research, and helping run clinics and hospitals—provides a window into how the profession has transformed. In vivid stories and essays, he explores the lived experience of psychiatric work and the daunting challenges of healing the mind amid ever-changing theoretical models. Recounting his intellectual, clinical, and personal adventures, Hellerstein finds unexpected poetry in hallways and waiting rooms; encounters with patients who are by turns baffling, frustrating, and inspiring; and the advances of science. Drawing on narrative-medicine approaches, The Couch, the Clinic, and the Scanner offers a perceptive and eloquent portrayal of the practice of psychiatry as it has struggled to define and redefine itself.

Sleep was taking over Anna’s life. Despite multiple alarm clocks and powerful stimulants, the young Atlanta lawyer could sleep for thirty or even fifty hours at a stretch. She stopped working and began losing weight because she couldn’t stay awake long enough to eat. Anna’s doctors didn't know how to help her until they tried an oddball drug, connected with a hunch that something produced by her body was putting her to sleep.

The Woman Who Couldn’t Wake Up tells Anna’s story—and the broader story of her diagnosis, idiopathic hypersomnia (IH), a shadowy sibling of narcolepsy that has emerged as a focus of sleep research and patient advocacy. Quinn Eastman explores the science around sleepiness, recounting how researchers have been searching for more than a century for the substances that tip the brain into slumber. He argues that investigation of IH could unlock new understandings of how sleep is regulated and controlled. Eastman foregrounds the experiences of people with IH, relating how publicity around Anna’s successful treatment helped others form a community. He shows how a group of patients who felt neglected or dismissed united to steer research toward their little-known disorder.

Sharing emerging science and powerful stories, this book testifies to the significance of underrecognized diseases and sheds new light on how our brains function, day and night. It is essential reading for anyone interested in sleep and sleep disorders, including those affected by or seeking to treat them.

This book is a go-to guide for all families seeking trustworthy information about the science and safety of vaccines. Paul A. Offit and Charlotte A. Moser—scientists and parents with decades of experience—equip readers with the facts they need to navigate vaccine decisions for the whole family, from babies to elders. In straightforward prose, they offer accessible and authoritative answers to today’s most common vaccine-related questions.

Offit and Moser explain how vaccines work, how they are made, and how they are tested. Chapters examine vaccine safety, ingredients, the workings of the immune system, and practical considerations from the implications of different medical conditions to missed doses. The book covers vaccines that have been available for decades as well as newer vaccines for illnesses such as RSV, COVID-19, and mpox, including both traditional and mRNA vaccines. The second half of the book is a guide to individual vaccines organized by age groups, including the first and second year of life, ages three to six, older children and teenagers, and adults. A timely resource for all families, this book allays unfounded fears and provides a clear, easy-to-understand picture of vaccines and vaccination.

Vaccines and Your Family is a revised and updated edition of Vaccines and Your Child (2011) that expands coverage to include all ages and addresses recent scientific progress. It explores the new recommendations and new questions regarding vaccines that have arisen in the intervening years.

This book is a go-to guide for all families seeking trustworthy information about the science and safety of vaccines. Paul A. Offit and Charlotte A. Moser—scientists and parents with decades of experience—equip readers with the facts they need to navigate vaccine decisions for the whole family, from babies to elders. In straightforward prose, they offer accessible and authoritative answers to today’s most common vaccine-related questions.

Offit and Moser explain how vaccines work, how they are made, and how they are tested. Chapters examine vaccine safety, ingredients, the workings of the immune system, and practical considerations from the implications of different medical conditions to missed doses. The book covers vaccines that have been available for decades as well as newer vaccines for illnesses such as RSV, COVID-19, and mpox, including both traditional and mRNA vaccines. The second half of the book is a guide to individual vaccines organized by age groups, including the first and second year of life, ages three to six, older children and teenagers, and adults. A timely resource for all families, this book allays unfounded fears and provides a clear, easy-to-understand picture of vaccines and vaccination.

Vaccines and Your Family is a revised and updated edition of Vaccines and Your Child (2011) that expands coverage to include all ages and addresses recent scientific progress. It explores the new recommendations and new questions regarding vaccines that have arisen in the intervening years.

Another pandemic is coming. It’s only a matter of time. It could be a novel flu virus, a biological weapon, even a prehistoric virus from melting glaciers—and we are not prepared. No one wants to endure the lockdowns and social isolation, the confusion and mixed messaging, or the fear and distrust that we experienced during the COVID-19 pandemic ever again. Yet that’s exactly the path we’re headed down if we erase the last pandemic from our memories.

In Before the Next Crisis, the public health expert Tista S. Ghosh implores us to remember. She shares the pandemic stories of everyday Americans from all walks of life—red and blue states, urban and rural areas. This gripping and relatable book recounts the real-life struggles that Americans faced: a Colorado grocery store manager dealing with harassment over mask policies, an Indiana police officer encountering a growing mental health crisis, a rural Wisconsin physician fighting rising public distrust, a California company leader struggling to keep frontline workers safe, and an Ohio health official grappling with the decision to cancel the city’s largest tourist event. These and other powerful narratives not only preserve the history of the pandemic but also highlight the lessons we must learn before the next health crisis—not just politicians or scientists, but all of us.

Another pandemic is coming. It’s only a matter of time. It could be a novel flu virus, a biological weapon, even a prehistoric virus from melting glaciers—and we are not prepared. No one wants to endure the lockdowns and social isolation, the confusion and mixed messaging, or the fear and distrust that we experienced during the COVID-19 pandemic ever again. Yet that’s exactly the path we’re headed down if we erase the last pandemic from our memories.

In Before the Next Crisis, the public health expert Tista S. Ghosh implores us to remember. She shares the pandemic stories of everyday Americans from all walks of life—red and blue states, urban and rural areas. This gripping and relatable book recounts the real-life struggles that Americans faced: a Colorado grocery store manager dealing with harassment over mask policies, an Indiana police officer encountering a growing mental health crisis, a rural Wisconsin physician fighting rising public distrust, a California company leader struggling to keep frontline workers safe, and an Ohio health official grappling with the decision to cancel the city’s largest tourist event. These and other powerful narratives not only preserve the history of the pandemic but also highlight the lessons we must learn before the next health crisis—not just politicians or scientists, but all of us.