Technology & Engineering

Computational methods and understanding computational models are important in modern drug discovery. The book focuses on computational approaches that can improve the development of in silico methodologies. It includes lead hit methods, docking algorithms, computational chiral compounds, structure-based drug design, GROMACS and NAMD, structural genomics, toxicity prediction, enzyme inhibitors and peptidomimetic therapeutics

The book bridges the gap between pharmaceutics and molecular modelling at the micro, meso and macro scale. It covers Lipinski's rule of five, nanoparticulate drug delivery, computational prediction of drug solubility and ability to cross blood brain barrier, computer-based simulation of pharmacokinetic parameters, virtual screening of mucoadhesive polymers, QSPR modelling, designing of 2D nanomaterials and role of principal component analysis.

This book unites the two sides of additive manufacturing: 1) the technical aspect of 3D printing of very different materials and 2) the disruptive consequences for value chains between producers, intermediaries, and customers due to modern business models. This is because 3D printing breaks with many existing business models: companies take over functions from their previous suppliers (following the "do-it-yourself" trend), intermediaries lose their livelihood (so-called "disintermediation"), manufacturers move their production to decentralized locations (e.g., retailers, car dealerships, or hospitals, so-called "decentralized production"), and (end) customers become much more intensive "prosumers" than marketing (as creator of this term) could ever imagine.

The business models of many existing companies from very different industries are becoming toxic, i.e., threatening their very existence, as in logistics and warehousing, industry, services, retail, or customer service. Conversely, there are also many opportunities for modern, existence-securing business models, which the book discusses in more detail. In this way, this book not only shows to a broad range of readers the dangers of disruptive 3D printing technology, but also offers solution approaches and procedural models for identifying new economic livelihoods and competitive advantages. Thanks to the collaboration of the two authors, a profound knowledge of already existing references and management models can be drawn upon.

New ceramic materials are highly appreciated due to their manifold features including mechanical properties, environmental uses, energy applications and many more. This work presents the latest research development and covers a broad range of topics from stabilized zirconia ceramics with enhanced functional properties to ceramic components in medical/biological applications.